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Transcriptional control of the Cryptosporidium life cycle

The parasite Cryptosporidium is a leading agent of diarrhoeal disease in young children, and a cause and consequence of chronic malnutrition1,2. There are no vaccines and only limited treatment options3. The parasite infects enterocytes, in which it engages in asexual and sexual replication4, both of which are essential to continued infection and transmission. However, their molecular mechanisms remain largely unclear5. Here we use single-cell RNA sequencing to reveal the gene expression programme of the entire Cryptosporidium parvum life cycle in culture and in infected animals. Diverging from the prevailing model6, we find support for only three intracellular stages: asexual type-I meronts, male gamonts and female gametes. We reveal a highly organized program for the assembly of components at each stage. Dissecting the underlying regulatory network, we identify the transcription factor Myb-M as the earliest determinant of male fate, in an organism that lacks genetic sex dete ....

United States , Chlamydomonas Reinhardtii , Muris Gen , Global Enteric Multicenter Study , Wkly Rep , Cell Host Microbe , Host Microbe , Cryptosporidium Muris , Plant Biol , Trends Plant Sci , Acids Res ,

2024 News - University of Maryland School of Medicine Launches Vaccine Development Program to Prevent Sepsis in Newborns

2024 News - University of Maryland School of Medicine Launches Vaccine Development Program to Prevent Sepsis in Newborns
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United States , Burkina Faso , Joseph Augustin Leprince , Karenl Kotloff , Miriam Laufer , Kathleenm Neuzil , Myronm Levine , Kathleen Neuzil , Strategic Advisory Group Of Experts , University Of Maryland School Medicine , Vaccine Development , National Academy Of Medicine , A University Of Maryland School Medicine , World Health Organization , Malaria Research , Global Health , Pediatric Center , Dean For Global Health , American Society Of Tropical Medicine , Maryland School , New England Journal , Bessie Grollman Distinguished Professor , Associate Dean , Infectious Diseases , Former Director , America Geoffrey Beene Foundation Builders ,

Can Vaccines Protect Children's Growth?

Can Vaccines Protect Children's Growth?
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Anthony Karumba , Kakamega County , Global Enteric Multicenter Study , Vaccine Impact ,

2017 News | University of Maryland School of Medicine

2017 News | University of Maryland School of Medicine
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United States , Burkina Faso , Karen Kotloff , Typhis Typhi , James Galen , Kathleenm Neuzil , Myronm Mike Levine , Theoderee Woodward , National Institute Of Allergy , Dean For Global Health , University Of Maryland School Medicine , University Of Maryland , World Health Organization , University Of Maryland School Medicine Center , International Vaccine Institute , Tel Aviv University , Vaccine Development , Merck Sharp Dohme Corp , Vaccinology Lectureship , Peter Hotez , National School , Tropical Medicine , Baylor College , Leadership Hall , Saharan Africa , Maryland School ,

Nigeria: Gates Foundation Lists Measures to Prevent Stillbirth, Infant Death in Low - Middle-Income Countries

Nigeria: Gates Foundation Lists Measures to Prevent Stillbirth, Infant Death in Low - Middle-Income Countries
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Melinda Gates , Bill Gates , Pneumonia Etiology Research Child Health Study , Gates Foundation , Child Health , Melinda Gates Foundation , Melinda French Gates , Mortality Prevention Surveillance , Global Enteric Multicenter Study , Saharan Africa , South Asia ,