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Risk of myocarditis and pericarditis after a COVID-19 mRNA vaccine booster and after COVID-19 in those with and without prior SARS-CoV-2 infection: A self-controlled case series analysis in England - Vimarsana News

Risk of myocarditis and pericarditis after a COVID-19 mRNA vaccine booster and after COVID-19 in those with and without prior SARS-CoV-2 infection: A self-controlled case series analysis in England

In a nationwide, self-controlled case series analysis conducted in England, Julia Stowe and colleagues investigate the effect of prior SARS CoV-2 infection on the risk of hospital admission for myocarditis or pericarditis after primary or booster vaccination and after a confirmed SARS-CoV-2 infection.

Source: plos.org
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19 - Vimarsana News

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Abstract While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXC...