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Expanding a lymph node, boosting a vaccine

For the first time, researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Genentech<u>, a member of the Roche Group,</u> found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered mechanical features and hosted higher numbers of various immune cell types that commonly are involved in immune responses against pathogens and cancers. Importantly, “jump-starting” lymph node expansion prior to administering a traditional vaccine against a melanoma-specific model antigen led to more effective and sustained anti-tumor responses in mice.  ....

Massachusetts Institute Of Technology , United States , Tufts University , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Benjamin Freedman , Katherine Williams , Maxence Dellacherie , Shannon Turley , Christina Tringides , Hamza Ijaz , Joel Gutierrez Estupinan , Giovanni Bovone , Alberto Elosegui Artola , Benjamin Boettner , Shawn Kang , Miguel Sobral , Robertp Pinkas , Alexander Najibi , Donald Ingber , David Mooney , Harvard Johna Paulson School Of Engineering , Farber Cancer Institute , Arts Sciences , National Institutes Of Health Cancer Institute ,

Lymph Node Expansion Enhances Vaccine Efficacy

Lymph Node Expansion Enhances Vaccine Efficacy
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United States , Katherine Williams , Shannon Turley , Maxence Dellacherie , Benjamin Freedman , Alberto Elosegui Artola , Benjamin Boettner , Joel Gutierrez Estupinan , Giovanni Bovone , Christina Tringides , Hamza Ijaz , Miguel Sobral , Shawn Kang , Robertp Pinkas , Alexander Najibi , Donald Ingber , David Mooney , Wyss Institute , Roche Group , Wyss Institute Founding Core Faculty , National Institutes Of Health Cancer Institute , Harvard Johna Paulson School Of Engineering , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences ,

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies. ....

United States , Maxence Dellacherie , Hamza Ijaz , Joel Gutierrez Estupinan , Giovanni Bovone , Robertp Pinkas , David Mooney , Shannon Turley , Alberto Elosegui Artola , Donald Ingber , Christina Tringides , Miguel Sobral , Benjamin Freedman , Shawn Kang , Alexander Najibi , Katherine Williams , Harvard Johna Paulson School Of Engineering , Wyss Institute , National Institutes Of Health Cancer Institute , Roche Group , Wyss Institute Founding Core Faculty , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical ,

Biomaterial vaccine enhances lymph node expansion following vaccination, boosting anti-tumor immunity

Biomaterial vaccine enhances lymph node expansion following vaccination, boosting anti-tumor immunity
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Shannon Turley , David Mooney , Alexander Najibi , Robertp Pinkas , Donald Ingber , Wyss Institute Founding Core Faculty , Harvard Johna Paulson School Of Engineering , Roche Group , Wyss Institute , Wyss Institute At Harvard University , Harvard University , Biologically Inspired Engineering , Harvard John , Applied Sciences , Nature Biomedical , Family Professor , Wyss Coordinated Immuno Engineering , Regenerative Medicine , Wyss Founding Director Donald Ingber , Nature Biomedical Engineering ,

Unveiling a polarized world -- in a single shot

Unveiling a polarized world -- in a single shot
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