Benjamin Boettner News Today : Breaking News, Live Updates & Top Stories | Vimarsana

For the first time, researchers from the&nbsp;Wyss Institute for Biologically Inspired Engineering at Harvard University,&nbsp;Harvard John A. Paulson School of Engineering and Applied Sciences&nbsp;(SEAS), and&nbsp;Genentech<u>, a member of the Roche Group,</u>&nbsp;found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered&nbsp;mechanical features&nbsp;and hosted higher nu...

<p>Hydrogels are already used in clinical practice for the delivery of drugs, and as lenses, bone cement, wound dressings, 3D scaffolds in tissue engineering and other applications. However, bonding different hydrogel polymers to one another has remained a challenge; yet it could enable numerous new applications. Now, Harvard Wyss and SEAS researchers pioneered a new method that uses a thin film of chitosan, a fibrous sugar-based material derived from the processed outer skeletons of shellfish, to make different hydrogels instantaneously and strongly stick to each other. They used their ...

<p>In the development of Parkinson&rsquo;s disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms. But without a test that can detect these changes, it&rsquo;s difficult to intervene early to more effectively slow disease progression.&nbsp;</p> <p>Researchers from the&nbsp;<a href="http://brighamandwomens.org/">Brigham and Women&rsquo;s Hospital</a>, a founding member of&nbsp;<a href="http://massgeneralbrigham.org/">Mass General Brigham</a>...

<p>Researchers have developed a human&nbsp;<em>in vitro</em>&nbsp;model that closely mimics the complexities of radiation-induced lung injury (RILI) and radiation dose sensitivity of the human lung. Using a previously developed microfluidic human Lung Alveolus Chip lined by human lung alveolar epithelial cells interfaced with lung capillary cells to recreate the alveolar-capillary interface&nbsp;<em>in vitro</em>, the researchers recapitulated many of the hallmarks of RILI, including radiation-induced DNA damage in lung tissue, cell-specific changes in...

T cell bispecific antibodies (TCBs) are an emerging class of immunotherapeutics with several TCBs approved by the FDA for the treatment of leukemias, lymphomas, and myelomas. TCBs label tumor cells with one of their ends, and attract immune cells with another end to coerce them into tumor cell killing. However, one major challenge in the development of TCBs are “on-target, off-tumor” toxicities at sites in the body that also express TCB-targeted antigens. A new collaboration of Jennifer Lewis’ group and researchers from the Roche Innovation Centers in Switzerland and Germany now created ...