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Boosting CAR-T cell therapies from under the

Boosting CAR-T cell therapies from under the
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Tufts University , United States , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Massachusetts Institute Of Technology , Miguel Sobral , Kwasi Adu Berchie , Robertp Pinkas , David Zhang , Joshua Brockman , Yutong Liu , David Mooney , Yoav Binenbaum , Donald Ingber , Dave Mooney , Benjamin Boettner , Drug Administration , Farber Cancer Institute , Beth Israel Deaconess Medical Center , University Of Wisconsin , Arts Sciences , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes , Method Of Research ,

Boosting CAR-T cell therapies from under the skin

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model. ....

United States , Miguel Sobral , Robertp Pinkas , Yoav Binenbaum , Yutong Liu , Donald Ingber , Dave Mooney , David Mooney , David Zhang , Joshua Brockman , Kwasi Adu Berchie , Drug Administration , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes Of Health , University Of Wisconsin , Wyss Institute , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical , Wyss Founding Core Faculty , Family Professor , Postdoctoral Fellow , Assistant Professor ,

A new glue, potentially also for you

A new glue, potentially also for you
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United States , David Mooney , Donald Ingber , Phoebe Kwon , Haley Jeffers , Mathew Lee , Juan Cintron Cruz , Dave Mooney , Robertp Pinkas , James Weaver , Daniel Kent , Research Scholar , Wyss Institute At Harvard University , Proceedings Of The National Academy Science , Wyss Research Associate Benjamin Freedman , Founding Wyss Institute Core Faculty , Harvard Johna Paulson School Of Engineering , Wyss Institute , National Institutes Of Health Institute On , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , National Academy , Family Professor , Tough Adhesives ,

Innovative Adhesive: Potential Game-Changer for Consumers

Innovative Adhesive: Potential Game-Changer for Consumers
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United States , Robertp Pinkas , Benjamin Boettner , David Mooney , Mathew Lee , James Weaver , Dave Mooney , Daniel Kent , Donald Ingber , Juan Cintron Cruz , Phoebe Kwon , Haley Jeffers , Wyss Research Associate Benjamin Freedman , National Institutes Of Health Institute On , Wyss Institute At Harvard University , Wyss Institute , Founding Wyss Institute Core Faculty , Proceedings Of The National Academy Science , Harvard Johna Paulson School Of Engineering , Research Scholar , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , National Academy , Family Professor ,

A new glue, potentially also for you

<p>Hydrogels are already used in clinical practice for the delivery of drugs, and as lenses, bone cement, wound dressings, 3D scaffolds in tissue engineering and other applications. However, bonding different hydrogel polymers to one another has remained a challenge; yet it could enable numerous new applications. Now, Harvard Wyss and SEAS researchers pioneered a new method that uses a thin film of chitosan, a fibrous sugar-based material derived from the processed outer skeletons of shellfish, to make different hydrogels instantaneously and strongly stick to each other. They used their approach to locally protect and cool tissues, seal vascular injuries, and prevent unwanted “surgical adhesions” of internal body surfaces. </p>
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University Of Massachusetts Medical School , United States , Massachusetts Institute Of Technology , Spaulding Rehabilitation Hospital , Tufts University , Boston University , Dave Mooney , Juan Cintron Cruz , Benjamin Boettner , Daniel Kent , David Mooney , Robertp Pinkas , Mathew Lee , Phoebe Kwon , James Weaver , Donald Ingber , Benjamin Freedman , Haley Jeffers , Wyss Institute , National Institutes Of Health Institute On , Proceedings Of The National Academy Science , Founding Wyss Institute Core Faculty , Farber Cancer Institute , Method Of Research , Wyss Institute At Harvard University , Wyss Research ,