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CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called 'T-cell enhancing scaffolds' (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in ...

<p>Hydrogels are already used in clinical practice for the delivery of drugs, and as lenses, bone cement, wound dressings, 3D scaffolds in tissue engineering and other applications. However, bonding different hydrogel polymers to one another has remained a challenge; yet it could enable numerous new applications. Now, Harvard Wyss and SEAS researchers pioneered a new method that uses a thin film of chitosan, a fibrous sugar-based material derived from the processed outer skeletons of shellfish, to make different hydrogels instantaneously and strongly stick to each other. They used their ...

The Loop held another 9-dash card, and the feature harness racing event was the second running of the new Manitoba Four-Year-Old Stake. Irish Melvin (Mystery Chase) took the lead from the word go and never looked back. He opened the race with a brisk 30-second opening quarter and mirrored that time in the second panel.

Charles Bonnici captained the ferry&#039;s maiden voyage. He explains what the job entails

St Patrick’s Athletic avoided a major FAI Cup upset away to First Division Longford Town at Bishopsgate on Sunday evening.