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Boosting CAR-T cell therapies from under the

Boosting CAR-T cell therapies from under the
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Tufts University , United States , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Massachusetts Institute Of Technology , Miguel Sobral , Kwasi Adu Berchie , Robertp Pinkas , David Zhang , Joshua Brockman , Yutong Liu , David Mooney , Yoav Binenbaum , Donald Ingber , Dave Mooney , Benjamin Boettner , Drug Administration , Farber Cancer Institute , Beth Israel Deaconess Medical Center , University Of Wisconsin , Arts Sciences , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes , Method Of Research ,

Boosting CAR-T cell therapies from under the skin

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model. ....

United States , Miguel Sobral , Robertp Pinkas , Yoav Binenbaum , Yutong Liu , Donald Ingber , Dave Mooney , David Mooney , David Zhang , Joshua Brockman , Kwasi Adu Berchie , Drug Administration , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes Of Health , University Of Wisconsin , Wyss Institute , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical , Wyss Founding Core Faculty , Family Professor , Postdoctoral Fellow , Assistant Professor ,

Biomaterial Injection Combines T Cell and Cancer Vaccine Treatments |

Biomaterial Injection Combines T Cell and Cancer Vaccine Treatments |
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Kwasi Adu Berchie , Harvard Wyss Institute ,

Biomaterial-delivered one-two punch boosts cancer immunotherapy

Biomaterial-delivered one-two punch boosts cancer immunotherapy
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United States , Maxence Dellacherie , Yoav Binenbaum , Donald Ingber , Alexander Stafford , Kwasi Adu Berchie , Yutong Liu , Joshua Brockman , Alexander Najibi , Miguel Sobral , Robertp Pinkas , David Mooney , David Zhang , Nikolaus Dimitrakakis , National Cancer Institute , Wyss Institute Immunomaterials Platform , Nature Communications , Wyss Institute , Harvard Johna Paulson School Of Engineering , National Science Foundation , National Institutes Of Health , Drug Administration , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences ,

Biomaterial-Delivered One-Two Punch Boosts Cancer Immunotherapy

Biomaterial-Delivered One-Two Punch Boosts Cancer Immunotherapy
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United States , Joshua Brockman , Alexander Stafford , Nikolaus Dimitrakakis , Alexander Najibi , Yutong Liu , Maxence Dellacherie , Donald Ingber , Benjamin Boettner , Kwasi Adu Berchie , David Zhang , Yoav Binenbaum , Miguel Sobral , Robertp Pinkas , David Mooney , Wyss Institute Immunomaterials Platform , Wyss Institute , Nature Communications , National Cancer Institute , National Science Foundation , National Institutes Of Health , Harvard Johna Paulson School Of Engineering , Drug Administration , Biologically Inspired Engineering , Harvard University , Harvard John ,