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Time for Mental Stress Testing in ANOCA?

Mental stress–induced myocardial ischemia is significantly associated with adverse cardiovascular events, particularly for women, but it may not always be linked to microvascular dysfunction. ....

New York , United States , Quingshan Geng , Coll Cardiol , Viola Vaccarino , Leslie Cho , Johanna Contreras , Journal Of The American College Cardiology , Cleveland Clinic Women Cardiovascular Center , Case Western Reserve Medical School , Guangdong Provincial Bureau Of Traditional Chinese Medicine , Technology Research Foundation , Cleveland Clinic Lerner School Of Medicine , School Of Medicine , Shenszhen People , American College , Medscape Cardiology , Stress Testing , Wilton Looney Distinguished Professor , Cardiovascular Research , Emory University , Rollins School , Public Health , Cardiovascular Disease , Women Committee , Cleveland Clinic ,

Frontiers | Significant Difference of Immune Cell Fractions and Their Correlations With Differential Expression Genes in Parkinson's Disease

Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD. However, the association between the peripheral immune system and CNS is remained to be elucidated. Here, we analyzed an incorporative substantial nigra expression data as well as another blood expression data using the CIBERSORT to obtain the 22 immune cells fraction and then explored the molecular function to identify the potential key immune cell types and genes of PD. We observed the proportions of naïve CD4 T cells, gamma delta T cells, resting NK cells, neutrophils in the blood, and regulatory T cells (Tregs) in the substantial nigra were significantly different between PD patients and healthy controls (HC). We identified p53-induced death domain protein 1 (PIDD1) as the hub gene of a Parkinson’s disease-related module. The set of neuron-spe ....

United States , J Neuroimmune Pharmacol , Felix Garza , Tregs Rosenkranz , Acta Neuropathol , Guangdong Province Key Laboratory Of Fermentation , National Natural Science Foundation Of China , Graphpad Software , Differential Gene Expression , Supplementary Table , Supplementary Figures , Enrichment Analysis , Kyoto Encyclopedia , Graphpad Prism , Supplementary Figure , National Natural Science Foundation , High Level Hospital Construction Project , Guangdong Province Key Laboratory , Enzyme Engineering , Supplementary Material , Med Abstract , Crossref Full Text , Meyer Zu Horste , Parkinson 39s Disease , Immune Cells , Substantia Nigra ,