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Age is just a number: Immune cell 'epigenetic clock' ticks independently of organism lifespan

Researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old. ....

Anoop Babu Vasandan , Caitlin Zebley , David Masopust , Andrew Soerens , Zhaoming Wang , April Mueller , Vaiva Vezys , Stephen Baylin , Charles Mullighan , Christopher Hiner , Ilaria Iacobucci , Harris Goldstein , Peter Jones , Ben Youngblood , Cure Foundation , University Of Minnesota , Jude Children Research Hospital , Jude Department Of Immunology , Alex Lemonade Stand Foundation , Van Andel Institute , National Institutes Of Health , Albert Einstein College Of Medicine , National Comprehensive Cancer Network , Jude Children , Research Hospital , Jude Department ,

Mission Bio Launches Sample Multiplexing for Tapestri to Unlock Critical Single-Cell Insights for Oncology and Genome Editing Markets

Mission Bio Launches Sample Multiplexing for Tapestri to Unlock Critical Single-Cell Insights for Oncology and Genome Editing Markets
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Ilaria Iacobucci , Anjali Pradhan , Agilent Technologies , Tapestri Pipeline Software , Jude Children Research Hospital , Consort Partners For Mission Bio , Mission Bio , Mayfield Fund , Department Of Pathology At St , Chief Product Officer , Principal Scientist , Jude Children , Research Hospital , Tapestri Platform , Novo Growth , Cota Capital ,

Forecasting Cancer-Linked Oncoprotein Condensate Formation

Forecasting Cancer-Linked Oncoprotein Condensate Formation
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Baylor College Of Medicine , United States , Bappaditya Chandra , Madan Babu , Scott Gorman , Ilaria Iacobucci , Brittany Pioso , Xin Zhou , Diana Mitrea , Daniel Jarosz , Charles Mullighan , David Baggett , John Bollinger , Swarnendu Tripathi , Jinghui Zhang , Yongsheng Li , Qingsong Gao , Hazheen Shirnekhi , Michael Edmonson , Richard Kriwacki , Benjamin Lang , Ramiz Somjee , Michael White , Stephen Yi , Nidhi Sahni , Stephen Rice ,

To wipe childhood cancer off map, scientists must chart its genomic landscape

To wipe childhood cancer off map, scientists must chart its genomic landscape
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United States , Ashley Hill , Michael Rusch , Pradyuamna Baviskar , R Jinghui Zhang , James Downing , Meenakshi Devidas , Ilaria Iacobucci , Diane Flasch , Mary Relling , Jian Wang , Stephen Rice , Xiaotu Ma , Sima Jeha , Danielas Gerhard , Colleen Reilly , Kathryn Roberts , Abdelrahman Elsayed , Jinghui Zhang , Sasi Arunachalam , Scott Newman , Deqing Pei , Scott Foy , Jun Yang , Xin Zhou , Debbie Payne Turner ,

Analysis reveals origins of a leukemia that straddles diagnostic categories

Analysis reveals origins of a leukemia that straddles diagnostic categories
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Cyrus Mehr , Kirsten Dickerson , Zhaohui Gu , Jing Ma , Ilaria Iacobucci , William Evans , Mary Relling , Ryan Hiltenbrand , Wenjian Yang , Tamara Westover , Xiaolong Chen , Xiaotu Ma , Jeffery Klco , Kathryn Roberts , Junj Yang , Charles Mullighan , Jinghui Zhang , Lindsey Montefiori , Cheng Chang , Beisi Xu , Henry Schueler , Sherif Abdelhamed , Shunsuke Kimura , Claudia Haferlach , Zhongshan Cheng , Sonja Bendig ,