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Age is just a number: Immune cell epigenetic clock ticks independently of organism lifespan

Researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old.

Anoop babu vasandanCaitlin zebleyDavid masopustAndrew soerensZhaoming wangApril muellerVaiva vezysStephen baylinCharles mullighanChristopher hinerIlaria iacobucciHarris goldsteinPeter jonesBen youngbloodCure foundationUniversity of minnesota

Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

United statesXin huangXu yangCharles mullighanSeth karolSteven kornblauJunj yangXiaofan zhuSheetal bhataraYizhen liYingchi zhangSatoshi yoshimuraNitin jainJiyang yuMarina konoplevaJingliao zhang

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Xu yangUnited statesXin huangJingliao zhangWilliam evansElias jabbourHiroto inabaCharles mullighanSeth karolYizhen liWenjian yangMark litzowSatoshi yoshimuraNitin jainHuanbin zhaoMarina konopleva

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Xu yangXin huangUnited statesMark litzowHuanbin zhaoSatoshi yoshimuraElias jabbourXiaofan zhuYizhen liYingchi zhangJingliao zhangSheetal bhataraSteven kornblauNitin jainWilliam evansSeth karol

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Xu yangUnited statesXin huangSeth karolWilliam evansWenjian yangSheetal bhataraJingliao zhangYingchi zhangSteven kornblauNitin jainCharles mullighanHiroto inabaElisabeth paiettaMarina konoplevaSatoshi yoshimura