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Age is just a number: Immune cell 'epigenetic clock' ticks independently of organism lifespan

Researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old. ....

Anoop Babu Vasandan , Caitlin Zebley , David Masopust , Andrew Soerens , Zhaoming Wang , April Mueller , Vaiva Vezys , Stephen Baylin , Charles Mullighan , Christopher Hiner , Ilaria Iacobucci , Harris Goldstein , Peter Jones , Ben Youngblood , Cure Foundation , University Of Minnesota , Jude Children Research Hospital , Jude Department Of Immunology , Alex Lemonade Stand Foundation , Van Andel Institute , National Institutes Of Health , Albert Einstein College Of Medicine , National Comprehensive Cancer Network , Jude Children , Research Hospital , Jude Department ,

Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%. ....

United States , Xin Huang , Xu Yang , Charles Mullighan , Seth Karol , Steven Kornblau , Junj Yang , Xiaofan Zhu , Sheetal Bhatara , Yizhen Li , Yingchi Zhang , Satoshi Yoshimura , Nitin Jain , Jiyang Yu , Marina Konopleva , Jingliao Zhang , Hiroto Inaba , William Evans , Wenjian Yang , Elisabeth Paietta , Elias Jabbour , Mark Litzow , Huanbin Zhao , Leukemia Research , Albert Einstein College Of Medicine , Children Research Hospital ,

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia
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Xu Yang , United States , Xin Huang , Jingliao Zhang , William Evans , Elias Jabbour , Hiroto Inaba , Charles Mullighan , Seth Karol , Yizhen Li , Wenjian Yang , Mark Litzow , Satoshi Yoshimura , Nitin Jain , Huanbin Zhao , Marina Konopleva , Elisabeth Paietta , Xiaofan Zhu , Sheetal Bhatara , Yingchi Zhang , Steven Kornblau , National Institutes Of Health , University Of Texas Md Anderson Cancer Center , Albert Einstein College Of Medicine , Baldrick Foundation , University Of Chicago ,

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Xu Yang , Xin Huang , United States , Mark Litzow , Huanbin Zhao , Satoshi Yoshimura , Elias Jabbour , Xiaofan Zhu , Yizhen Li , Yingchi Zhang , Jingliao Zhang , Sheetal Bhatara , Steven Kornblau , Nitin Jain , William Evans , Seth Karol , Wenjian Yang , Marina Konopleva , Hiroto Inaba , Charles Mullighan , Elisabeth Paietta , Drug Administration , Children Research Hospital , National Institutes Of Health , Albert Einstein College Of Medicine , Department Of Defense ,

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Xu Yang , United States , Xin Huang , Seth Karol , William Evans , Wenjian Yang , Sheetal Bhatara , Jingliao Zhang , Yingchi Zhang , Steven Kornblau , Nitin Jain , Charles Mullighan , Hiroto Inaba , Elisabeth Paietta , Marina Konopleva , Satoshi Yoshimura , Elias Jabbour , Mark Litzow , Huanbin Zhao , Xiaofan Zhu , Yizhen Li , National Cancer Comprehensive Center , Albert Einstein College Of Medicine , Department Of Defense , National Institutes Of Health , Children Research Hospital ,