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Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.
Hyperdiploidy is a genetic condition observed in cancer cells, where the cells contain more chromosomes than usual.
Date Time Risk-directed childhood leukemia treatment takes a step forward Corresponding author Ching-Hon Pui, M.D., St. Jude Oncology Department chair, helped discover how genomic analysis can improve outcomes for children with acute lymphoblastic leukemia. Comprehensive genomic analyses have helped researchers identify more than 20 subtypes of acute lymphoblastic leukemia (ALL) based on the genetic mutations that drive the disease. Research led by St. Jude Children’s Research Hospital scientists showed that combining these data with leukemia response measurements improves prediction of r...