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Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

Texas , United-states , Xin-huang , Zhejiang , China , Peking , Beijing , Xu-yang , Shaanxi , Charles-mullighan , Seth-karol , Steven-kornblau

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Xu-yang , Shaanxi , China , Texas , United-states , Peking , Beijing , Xin-huang , Zhejiang , Jingliao-zhang , William-evans , Elias-jabbour

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Xu-yang , Shaanxi , China , Peking , Beijing , Xin-huang , Zhejiang , Texas , United-states , Mark-litzow , Huanbin-zhao , Satoshi-yoshimura

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Xu-yang , Shaanxi , China , Texas , United-states , Xin-huang , Zhejiang , Peking , Beijing , Seth-karol , William-evans , Wenjian-yang

Study reveals genetic variant linked to increased risk of leukemia in Hispanic/Latino children

Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States.

San-francisco , California , United-states , Boston , Massachusetts , China , Stanford-university , Dana-farber-cancer-institute , Berkeley , Jun-yang , Jiangxi , Guangzhou

USC researchers find genetic variant contribu

<p style="text-align:start">Children of Hispanic/Latino origin are 30-40% more likely to get Acute lymphoblastic leukemia (ALL) than non-Hispanic white children. However, the exact genetic basis and cause of that increased risk are unknown. Now researchers have revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL. The research team focused on the <em>IKZF1 </em>gene, known to relate to ALL but never before linked with ethnic risk disparities. Using genetic fine-mapping analysis, they independently analyzed each position along the gene—known as a single nucleotide polymorphism (SNP)—to determine whether having a certain variant increased ALL risk. They found three independent SNPs linked to higher ALL incidence, one of which was present in about 30% of people of Hispanic/Latino origin in the U.S. and less than 1%  of people of primarily European origin. Although overall risk for the disease is low across all racial/ethnic groups, children with that gene variant, located at SNP rs76880433, were 1.44 times as likely to develop ALL as children without the variant. They also found that the risk variant reduced chromatin accessibility, preventing <em>IKZF1 </em>proteins from being fully expressed. In experiments with stem cells, the team found that “knocking out” the <em>IKZF1 </em>gene caused B-cell development to stall in its early stages.</p>

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New-york , United-states , Donglei , Jiangsu , China , Dana-farber-cancer-institute , Massachusetts , California , Jun-yang , Jiangxi , Stanford-university , Boston

USC researchers find genetic variant contribu

USC researchers find genetic variant contribu
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

California , United-states , Guangzhou , Guangdong , China , Jun-yang , Jiangxi , Boston , Massachusetts , Stanford-university , Berkeley , San-francisco

St. Jude Children's researchers better define hyperdiploidy in childhood B-ALL

Hyperdiploidy is a genetic condition observed in cancer cells, where the cells contain more chromosomes than usual.

National-university-hospital , Singapore-general- , Singapore , Kathryn-roberts , Sima-jeha , Lauren-rowland , Cheng , Yoshihiro-gocho , Emily-ashcraft , Shawn-lee , Wenjian-yang , Junj-yang

New research refines definition and hones treatment of hyperdiploid leukemia

New research refines definition and hones treatment of hyperdiploid leukemia
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Kathryn-roberts , Wenjian-yang , Emily-ashcraft , Hiroto-inaba , Seth-karol , Sima-jeha , Cheng , Lauren-rowland , Mary-relling , Yoshihiro-gocho , Junj-yang , William-evans

Mushroom on the shelves for functional fungi?

Would you eat fungus grown on the head of a Himalayan caterpillar? If you've tried the functional cordyceps mushroom, the answer's yes.

Lei-feng , Zhejiang , China , Singapore , United-kingdom , London , City-of , Amsterdam , Noord-holland , Netherlands , Chinese , Gaoxing-ma