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Investigating a role for complement in gene therapy

Immunology expert discusses the complement system, immunogenicity challenges in AAV-mediated gene therapy, and more ....

Klaudia Kuranda , Anna Majowicz , Technology Department At Spark Therapeutics , Technology Department , Editorial Article , Spark Therapeutics , Preclinical Immunology Lead , Svar Life Science , Functional Complement Assays , Complement System , Complement System Alternative Pathway , Complement System Classical , The Importance Of Investigating Complement System In Gene Therapy Selectscience Aav , Av Gene Therapy , Omplement Activiation , Av Capsid Specifict Cells , Aav Vectors ,

WHO for introduction of dengue vaccine in India

As dengue cases, particularly in Delhi, show a steep increase, the World Health Organisation has recommended introduction of dengue vaccine in high burden countries including India. ....

World Health Organisation , Drugs Controller General , Dengue Prevention , Dengue Vaccine , Engue Vaccination In India ,

Savings Potential With Biosimilars

Jonathan Kay, MD, and Kimberly C. Chen DO, MSHLM, define what a biosimilar is and discuss the potential for a lower cost than the reference product. ....

Jonathan Kay , Kimberlyc Chen , Biosimilars Stakeholder Summit , Interchangeable Biosimilars , Inflammatory Diseases , Reference Product , Lower Cost , Clinical Trial ,

Frontiers | Comparison of vaccination schedules for foot-and-mouth disease among cattle and sheep in Mongolia

Vaccines are a critical tool for the control strategy for foot-and-mouth disease (FMD) in Mongolia where sporadic outbreaks regularly occur. A two-dose primary vaccination course is recommended for most commercial vaccines though this can be logistically challenging to deliver among nomadic pastoralist systems which predominate in the country. Although there is evidence that very high potency vaccines can provide prolonged duration of immunity, this has not been demonstrated under field conditions using commercially available vaccines. This study compared neutralising titres to a O/ME-SA/Panasia strain over a six-month period following either a two-dose primary course or a single double-dose vaccination among Mongolian sheep and cattle using a 6.0 PD50 vaccine. Titres were not significantly different between groups except in sheep at six-months post vaccination when the single double-dose group had significantly lower titres. These results indicate the single double-dose regimen may be ....

United Kingdom , United States , Isle Of Wight , World Organisation For Animal Health , Sciences Research Council , World Bank Livestock Commercialization Project , Pirbright Institute , Rural Affairs Defra , Routledge Handbook Of Latin American Development , Boston College Department Of Economics , Central Veterinary Laboratory , European Union , Agriculture Organization Of The United Nations , World Organization For Animal Health , Department For Environment , Authority For Veterinary Services , European Commission , Statistical Software Components , World Reference Laboratory , Springer International Publishing , Orkhon Aimag , State Central Veterinary Laboratory , Reference Laboratory , General Authority , Veterinary Services , Agriculture Organization ,

MyJournals.org - Science - 'Immunogenicity and safety of COVID-19 BNT162b2 booster vaccine in end-stage kidney disease patients receiving haemodialysis in Yogyakarta, Indonesia: a cohort prospective study' (BMC Nephrology)

MyJournals.org - Science - Immunogenicity and safety of COVID-19 BNT162b2 booster vaccine in end-stage kidney disease patients receiving haemodialysis in Yogyakarta, Indonesia: a cohort prospective study (BMC Nephrology) ....

Covid 19 , Mend Stage , Ndonesia ,