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Targeting prostate tumor low–molecular weight tyrosine phosphatase for oxidation-sensitizing therapy

Targeting prostate tumor low–molecular weight tyrosine phosphatase for oxidation-sensitizing therapy
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , Transcriptome Atlas , University Of California Santa Cruz , Prostate Cancer Biorepository Network , Caris Life Sciences , Cancer Genome Atlas , Prostate Cancer Transcriptome Atlas , California Santa Cruz , Score Analysis , Pathway Analysis , Ingenuity Pathway Analysis ,

Study reveals significant health benefits of golden berries in diabetic and obese rats

The effects of a Golden Berry (Physalis peruviana)-enriched diet on insulin resistance and obesity. ....

United States , Berry Physalis , Industrial University Of Santander , Colombian Corporation For Agricultural Research , Golden Berry , Daily Consumption , Has Been Shown , Insulin Resistance , Obese Rats , Image Credit , South American , Colombian Corporation , Agricultural Research , Industrial University , Ingenuity Pathway Analysis , Graphpad Prism , High Density Lipoprotein , Orthogonal Signal Correction , Partial Least Squares Discriminant Analysis , Cyclocitral Glucuronide , Pipecolic Acid , Blood Sugar , High Blood Sugar , Insulin Resistance , Metabolic Disorders , Metabolic Syndrome ,

Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer

Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Broad Institute Depmap , Cancer Genome Atlas , Cancer Dependency Map Portal , Broad Institute , Kyoto Encyclopedia , Ingenuity Pathway Analysis ,

Apoptotic stress causes mtDNA release during senescence and drives the SASP

Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP), requires BAX and BAK macropores enabling the release of mitochondrial DNA (mtDNA) into the cytosol. Cytosolic mtDNA in turn activates the cGAS–STING pathway, a major regulator of the SASP. We find that inhibition of MOMP in vivo decreases inflammatory markers and improves healthspan in aged mice. Our results reveal that apoptosis and senescence are regulated by similar mitochondria-depende ....

United Kingdom , Adooq Biosciences , Tocris Bioscience , Antifade Mountant , Gencode Grch , Bruker Ct , Rnalater Qiagen , Dynabeads Invitrogen , Skyscan Nrecon , Zeiss Airyscan , Octo Dissociator Miltenyi , Analysis Software , Imol Polish Academy Of Sciences , Huygens Deconvolution Software , University Of Glasgow Animal Welfare , Pall Corporation , Thermo Fisher , National Institute On Aging , United Kingdom Home Office , Thermo Fisher Scientific , Atlanta Biological , Absolute Human Mitochondrial , Number Quantification , Tissue Kit , Qiaquick Nucleotide Removal Kit , Agilent Seahorse ,

Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

United States , Baden Wüberg , Palo Alto , Ann Arbor , San Diego , Nordrhein Westfalen , Goodenough Heuser , Isonet Liu , Smith Yang , Gmp Muthaiyan Shanmugam , Tetrahymena Urbanska , Idas Bicka , Leica Microsystems , Dzeja Terzic , Bonini Nelson , Jacek Gaertig , Idas Grossman Haham , Anna Osinka , Rudolph Cox , Ewa Joachimiak , Veiga Leprevost , Tegunov Cramer , Avrin Ghanaeian , Sumita Majhi , Bui Ishikawa , Orias Rasmussen ,