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Surgery with locking plate or hemiarthroplasty versus nonoperative treatment of 3–4-part proximal humerus fractures in older patients (NITEP): An open-label randomized trial

In a randomized controlled trial, Antti P Launonen and team compare outcomes of non-operative to operative treatment in patients aged ≥ 60 years with 3-4 part dislocated proximal humerus fractures. ....

Kanta Hame Region , Central Finland , Keski Suomi , Norra Savolax , Uppsala Lan , Eteläuomen Läi , Peter Heath , Seija Rautiainen , R Foundation For Statistical Computing , Euroqol Group , Regional Ethics Committee Of Tampere University Hospital , Estonia Medical Centre , Tampere University Hospital , Uppsala University Hospitals , Tartu University Hospital , Karolinska University Hospital , Academy Of Finland Terveyden , Creative Commons Attribution License , Institutional Data Access , Murley Score , Nordic Innovative Trial , Evaluate Osteoporotic Fractures , Oxford Shoulder Score , Central Finland Hospital , North Estonia Medical Centre , Viborg Regional Hospital ,

Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials

In a secondary analysis of clinical trial data, Clara Pons-Duran and colleagues study clinical malaria during pregnancy among adolescent and adult women in Benin, Gabon, Kenya, Mozambique, and Tanzania between 2009 and 2014. ....

United States , Benin General , Province De La Ngounie , Eteläuomen Läi , Papua New Guinea , Aina Casellas , Excelencia Severo Ochoa , Centers For Disease , Spanish Ministry Of Education , Spanish Ministry Of Science , Us Centers For Disease , Stata Corporation , Mahidol Oxford Tropical Medicine Research Unit , Ethics Committee Of The Hospital Cl , Saharan Africa , Saharan African , Creative Commons , Institutional Data Access , Spanish Ministry , Vocational Training , Generalitat De Catalunya , Editorial Board , Pregnancy Preventive Alternative Drugs , College Station , Ethics Committee , Disease Control ,

Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials

In a secondary analysis of clinical trial data, Clara Pons-Duran and colleagues study clinical malaria during pregnancy among adolescent and adult women in Benin, Gabon, Kenya, Mozambique, and Tanzania between 2009 and 2014. ....

United States , Benin General , Province De La Ngounie , Eteläuomen Läi , Papua New Guinea , Aina Casellas , Excelencia Severo Ochoa , Centers For Disease , Spanish Ministry Of Education , Spanish Ministry Of Science , Us Centers For Disease , Stata Corporation , Mahidol Oxford Tropical Medicine Research Unit , Ethics Committee Of The Hospital Cl , Saharan Africa , Saharan African , Creative Commons , Institutional Data Access , Spanish Ministry , Vocational Training , Generalitat De Catalunya , Editorial Board , Pregnancy Preventive Alternative Drugs , College Station , Ethics Committee , Disease Control ,

Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis

Geert-Jan Geersing and colleagues assess the capability of ruling-out pulmonary embolism by available diagnostic strategies across a range of healthcare settings. ....

United States , Sanjay Basu , Bristol Myers Squibb , Dutch Research Council , International Society On Thrombosis , Harvard Medical School , Principia Biopharma Inc , University Of Ottawa , Stroke Foundation Of Canada , Sanofi Company , Netherlands Organisation For Health Research , Department Of Medicine , Pulmonary Embolism Rule Out Criteria , Geersingg J , Creative Commons Attribution License , Institutional Data Access , Netherlands Organisation , Health Research , Dutch Heart , Venous Thromboembolism , Clinician Scientist , Stroke Foundation , International Society , Preferred Reporting Items , Systematic Reviews , Diagnostic Test Accuracy ,

Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial

Induction of labour may be necessary when pregnancies reach 41 weeks of gestation.
Ripening methods include mechanical and pharmacological options and both are currently used in pregnancies that reach 41 weeks of gestation.
Mechanical cervical ripening leads to less uterine tachysystole and less fetal heart rate anomalies than pharmacological methods.
Whether mechanical methods are associated with reduced perinatal morbidity in prolonged pregnancies in comparison with pharmacological methods needed to be investigated by a sufficiently powered randomised trial.
What did the researchers do and find?
We conducted a trial to compare cervical ripening with a silicone double-balloon catheter (mechanical method) to cervical ripening with a vaginal dinoprostone slow-release system (pharmacological method) among women with prolonged pregnancies. ....

United Kingdom , France General , Elie Azria , Celine Lengelle , Gordonc Smith , Gilles Kayem , Muriel Doret , Camille Le Ray , Cyril Huissoud , Philipe Deruelle , Elie Guichard , Renaud Respaud , Bruno Langer , Marie Victoire Senat , Damien Subtil , Yoann Desvignes Martine Gardin , Christophe Vayssiere , Charles Garabedjan , Thomas Schmitz , Cambridge University , Institutional Data Access Ethics Committee , Region Centre , Creative Commons Attribution License , Institutional Data Access , Ethics Committee , French Ministry ,