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A single injection every 3 months of a novel drug that targets the lipid metabolism enzyme ANGPTL3 resulted in substantial reductions in LDL cholesterol in patients with HoFH in the phase 2 GATEWAY trial.
Children and adolescents with homozygous familial hypercholesterolemia could benefit from lomitapide therapy, suggests a trial, although safety concerns and upcoming novel drugs question its place.
'If people start eating vegetarian or vegan diets from an early age, the potential for reducing the risk of cardiovascular disease caused by blocked arteries is substantial,' says study author.
The relatively high rates of overweight and obesity among patients with familial hypercholesterolemia should be addressed to reduce apparent impact on coronary artery disease risk, suggests a UK study.
Use of lipid and diabetes medications are lower 15 years after bariatric surgery, compared with patients with obesity who didn't undergo such surgery, in a large population-based study.