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FDA Approval Insights: Adjuvant Nivolumab in Completely Resected Stage IIB/C Melanoma

Dr Weber discusses the FDA approval of adjuvant nivolumab for patients with completely resected stage IIB/C melanoma, key efficacy data from the CheckMate76K trial, and potential future directions for PD-1 inhibitor–based combinations in the melanoma treatment paradigm. ....

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Dr Weber on Survival Outcomes With mRNA-4157 Plus Pembrolizumab in High-Risk Melanoma

Jeffrey S. Weber, MD, PhD, discusses findings from the phase 2b mRNA-4157-P201/KEYNOTE-942 trial of mRNA-4157 in combination with pembrolizumab in resected high-risk melanoma. ....

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Dr Simeone on the EVEREST-1 Trial Evaluating A2B530 in Solid Tumors

Diane M. Simeone, MD, discusses the phase 1/2 EVEREST-1 trial evaluating the autologous CAR T-cell therapy A2B530 in patients with solid tumors.
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Reducing the likelihood of melanoma recurring or causing death by 44 percent

Reducing the likelihood of melanoma recurring or causing death by 44 percent
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Cancer Vaccine Combo a 'Potential Major Breakthrough' in Skin Cancer

The addition of a personalized cancer vaccine to Keytruda led to a 44% reduction in the risk of death or recurrence in certain patients with melanoma. ....

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