​TB vaccines, diagnostics and biomarker discovery: the MRC Gambia TB case-contact platform
The TB case-contact platform at the MRC Unit in The Gambia provides a unique opportunity for analysing immunity to TB across the spectrum of infection and disease. MRCG has been involved in several multi-site studies to define correlates of protective immunity to TB. However, until recently these have been mainly blood-derived. The establishment of bronchoscopy and single-cell RNA sequencing at MRCG has paved the way for identification of correlates of protection at the site of infection for rational development of next generation vaccines.