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Repurposed Protease Regulates Key Signaling Protein

Repurposed Protease Regulates Key Signaling Protein
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Fangfang Lu , Yingdi Wang , Chia Hsueh Lee , Hongtu Zhao , Matthew Freeman , Yaxin Dai , Jude Department Of Structural Biology , Wellcome Trust Investigator , University Of Oxford , National Institutes Of Health , Jude Children Research Hospital , Molecular Cell , Jude Children , Research Hospital , Jude Department , National Institutes , Wellcome Trust Investigator Awards ,

Repurposed protease controls important signaling molecule-activating protein

Efficient communication between cells is vital for many biological processes, such as recruiting immune cells to combat disease. The rapid release of at least 80 signaling molecules, including tumor necrosis factor and epidermal growth factor, is controlled by a membrane-bound protease called ADAM17. ....

Hongtu Zhao , Yingdi Wang , Yaxin Dai , Matthew Freeman , Chia Hsueh Lee , Fangfang Lu , University Of Oxford , Jude Department Of Structural Biology , Jude Children Research Hospital , Jude Department , Structural Biology , Jude Children , Research Hospital , Molecular Cell ,

The GPCR Puzzle: New Research Reveals Molecular Origins of Function for a Key Drug Target

Scientists at St. Jude Children's Research Hospital, collaborating internationally, used data science, pharmacology, and structural details to explore at the atomic level how each amino acid in the adrenaline-binding receptor affects its activity when interacting with this natural ligand. They di ....

United Kingdom , United States , Georgej Pedersen , Maria Marti Solano , Zhaowen Luo , Manbir Sandhu , Franziska Heydenreich , Brian Kobilka , Briank Kobilka , Franziskam Heydenreich , Michel Bouvier , M Madan Babu , Institute For Research , Stanford University School Of Medicine , Wellcome Trust Institutional Strategic Support Fund , Department Of Biochemistry , American Heart Association , Isaac Newton , Cancer Of The University Montreal , United Kingdom Medical Research Council , Royal Society University , University Of Montreal , Drug Administration , Jude Research Collaborative , Philipps University Of Marburg , Cambridge University ,

GPCR structure: Research reveals molecular origins of function for a key drug target

GPCR structure: Research reveals molecular origins of function for a key drug target
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United Kingdom , Georgej Pedersen , Brian Kobilka , M Madan Babu , Michel Bouvier , Franziska Heydenreich , Philipps University Of Marburg , Stanford University , Stanford University School Of Medicine , Jude Research Collaborative , University Of Montreal , Department Of Biochemistry , Laboratory Of Molecular Biology , Jude Department Of Structural Biology , Cancer Of The University Montreal , Cambridge University , Institute For Research , Molecular Biology , Structural Biology , Data Driven Discovery , Endowed Chair , Biological Data , Philipps University , Molecular Medicine , General Director , Stanford University School ,

Collaborative Complexity of Proteins in Parkinson's Disease Unveiled

In a significant breakthrough, scientists have disclosed the complex structures of two proteins linked to late-onset Parkinson’s disease. ....

Iji Sun , Hanwen Zhu , Jude Children Research Hospital , Jude Department Of Structural Biology , Jude Children , Research Hospital , Jude Department , Structural Biology , Parkinsons Disease , Protein Structures , Protein Change , Ellular Trafficking , Drug Design ,