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investors: Thinking of KBC, stumped by KYC? Some answers for MF investors

While the process of doing KYC once again looks simple, investors, distributors, and investment advisors have been complaining that even after submitting the required documents for KYC, there are delays in updating them at the KRAs' end. Unless the KYC is approved, the AMC could reject your application for fresh investments.

India , Exchange-board-of-india , Know-your-customer , Exchange-board , Income-tax , Aadhaar-seeding- , Investors , Kyc , Mf , Kras , Amc

KRAs: KRAs issue guidelines for simpler KYC process

Of these, 73% of the KYC records are under 'KYC Validated' status, 15% are under 'KYC Registered' status and the remaining 12% are under 'KYC On-Hold' status.

Mumbai , Maharashtra , India , Aadhaar-seeding- , Kras , Cams , Kyc , Investors , Guidelines , Kyc-process ,

Broader KRAS inhibition methods include chaperoning, gluing, vaccinating

The existence of two approved therapies, Lumakras (sotorasib, Amgen Inc.) and Karzati (adagrasib, Mirati Therapeutics Inc.), has been a triumphant success against KRAS, a protein that was once considered undruggable. KRAS is the most frequently mutated oncogene in solid tumors. KRAS driver mutations are found in about 30% of non-small-cell lung cancers (NSCLC), about half of colorectal cancers, and more than 90% of pancreatic cancers. Lumakras and Karzati both target the G12C mutation. Inhibitors that target other mutations, like G12D, are now making their way through preclinical and clinical development, while some companies are developing therapies that would target mutated KRAS more broadly, irrespective of the specific mutation that is activating the protein.

Mirati-therapeutics-inc , Amgen-inc , Bioworld-science , Cancer , Revolution-medicines-inc- , Pancreatic-cancer , Non-small-cell-lung-cancer , Kras , Elicio-therapeutics-inc- , Vaccines , Quanta-therapeutics-inc-

Performance review is not an employee's enemy, here's how you can use it to your advantage

Performance reviews can cause anxiety among employees who are evaluated based on their performance and given feedback. Presenting strengths, leveraging feedback, and integrating AI are crucial for growth and success in the evaluation process.

Yadhu-kishore-nandikolla , Gunjandeep-kaur , Human-resources , Massmutual-india , Might-also-like , Performance-review , Appraisal , Employees , Hr , Goals , Kras

Off the Hookipa: Roche terminates $1B deal

Hookipa Pharma Inc.’s nearly $1 billion collaboration with Roche Holding AG dissolved along with 30% of the company’s staff. The New York-based company said Roche ended the October 2022 deal involving the HB-700 program in treating KRAS mutated cancers but did not say why the agreement fell apart.

Andrew-berens , Roche-holding , Hookipa-pharma-inc , Hookipa-pharma , New-york-based , Bioworld , Gilead-sciences-inc- , Kras , Hookipa-pharma-inc- , Hb-700 , Roche-group-ag , Deals-andm-amp-a

Targeted Colorectal Cancer Combo Improves QoL

Patients with metastatic colorectal cancer who have the KRAS G12C mutation demonstrated improved quality of life following sotorasib and panitumumab compared with standard therapy.

Memorial-sloan-kettering-cancer-center , New-york , United-states , Berlin , Germany , Rona-yaeger , University-of-medicine , European-organisation-for-research , New-england-journal , Brief-pain-inventory , European-organisation , Cancer-core

CNN News Central

that's the far right bloc that has been a persistent thorn in the pseudoof the leadership team. now with speaker johnson. they tended to try to scuttle this deal that johnson cut with chuck schumer. they believe d it spent too muc money and demanded for severe restrictions on the southern border with mexico. things that the the kras would not accept. johnson try ining to kut a deal tout some conservative victories. he was open to discussing the concerns of the far right members, but just moments ago, say that he would not side with those concerns and would stick to the agreement he cut with chuck schumer. when i asked bob good a about this, one of the eight members that kevin mccarthy was oust ed by. he made clear he was opposed to what johnson is doing, but he was not going to try to push johnson out of the speakership. >> how kiss adisappointed are yu

Mike-johnson , Deal , Chuck-schumer , Bloc , Speaker-johnson , Leadership-team , Pseudoof , Thorn , Border , Things , Money , Victories

KRAS allosteric mapping may open new therapeutic opportunities

In an article published on Dec. 18, 2023, in Nature, researchers from the Centre for Genomic Regulation in Barcelona (Spain) and Wellcome Sanger Institute in Hinxton (U.K.) reported achieving a milestone regarding KRAS targeting in cancer. The team quantified the impact of >26,000 KRAS variants and how these mutations affected protein folding and its interaction with the six main effectors – RAF1, PIK3CG, RALGDS, SOS1, K27 and K55.

Spain , Centre-for-genomic-regulation , Wellcome-sanger-institute-in-hinxton , Genomic-regulation , Wellcome-sanger-institute , Kras , Allosteric-mapping , Kras-binding-sites , Mutations ,