Immunoassay research with Lumit™ : Get Quote, RFQ, Price or Buy
This product profile describes the features and advantages of Lumit™ for immunoassay research.
Source: news-medical.net
Labeling Kit News Today : Breaking News, Live Updates & Top Stories | Vimarsana
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Invitrogen™ Qtracker™ 655 Cell Labeling Kit from Thermo Fisher Scientific
Read independent reviews on Invitrogen™ Qtracker™ 655 Cell Labeling Kit from Thermo Fisher Scientific on SelectScience
Source: selectscience.net
B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes
Abstract Cancer immunotherapy with 4-1BB agonists has limited further clinical development because of dose-limiting toxicity. Here, we developed a bispecific antibody (bsAb; B7-H3×4-1BB), targeting human B7-H3 (hB7-H3) and mouse or human 4-1BB, to restrict the 4-1BB stimulation in tumors. B7-H3×m4-1BB elicited a 4-1BB–dependent antitumor response in hB7-H3–overexpressing tumor models without systemic toxicity. BsAb primarily targets CD8 T cells in the tumor and increases their proliferation and cytokine production. Among the CD8 T cell population in the tumor, 4-1BB is solely expressed ...
Source: sciencemag.org