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Microglial cell response to experimental periodontal disease | Journal of Neuroinflammation

Microglial activation is critical for modulating the neuroinflammatory process and the pathological progression of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglia are involved in forming barriers around extracellular neuritic plaques and the phagocytosis of β-amyloid peptide (Aβ). In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells. Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Maxillary bone loss and local periodontal tissue inflammation associated with the development of PD were confirmed by morphometric bone analysis and cytokine expression, respectively. The frequency and the total number of activated microglia (CD45+ CD11b+ MHCII+) in the brain were analyzed by flow cytometry. Mouse m ....

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A blood-based marker of mitochondrial DNA damage in Parkinson's disease | Science Translational Medicine

A blood-based marker of mitochondrial DNA damage in Parkinson's disease | Science Translational Medicine
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United States , Blue Rock , Vanqua Bio , Resolight Roche , Genzyme Sanofi , Science Center , Scientist Office Senior Clinical Academic Fellowship , Critical Path For Parkinson Consortium , Ethical Committee , Graphpad Prism Software , Pepper Center , Busch Biomedical Research , Duke University Of Memory Disorders Clinic , Metabolism Seed Grant Program , National Neurological Institutec Mondino , Research Council Of Australia Leadership Fellowship , Parkinson Foundation , Movement Disorders , Bernicee Bumpus Foundation , Research Council , National Health , Oregon Health , Northwestern University , Movement Disorder Society , Duke University , Columbia University Medical Center ,

Development of diagnostic algorithm using machine learning for distinguishing between active tuberculosis and latent tuberculosis infection | BMC Infectious Diseases

The discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. The present study aims to investigate the value of diagnostic models established by machine learning based on multiple laboratory data for distinguishing Mycobacterium tuberculosis (Mtb) infection status. T-SPOT, lymphocyte characteristic detection, and routine laboratory tests were performed on participants. Diagnostic models were built according to various algorithms. A total of 892 participants (468 ATB and 424 LTBI) and another 263 participants (125 ATB and 138 LTBI), were respectively enrolled at Tongji Hospital (discovery cohort) and Sino-French New City Hospital (validation cohort). Receiver operating characteristic (ROC) curve analysis showed that the value of individual indicator for differentiating ATB from LTBI was limited (area under the ROC curve (AUC) < 0.8). A total of 28 models were successfully established using machine learning. Among t ....

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Ring stage classification of Babesia microti and Plasmodium falciparum using optical diffraction 3D tomographic technique | Parasites & Vectors

Babesia is an intraerythrocytic parasite often misdiagnosed as a malaria parasite, leading to inappropriate treatment of the disease especially in co-endemic areas. In recent years, optical diffraction tomography (ODT) has shown great potential in the field of pathogen detection by quantification of three-dimensional (3D) imaging tomograms. The 3D imaging of biological cells is crucial to investigate and provide valuable information about the mechanisms behind the pathophysiology of cells and tissues. The early ring stage of P. falciparum were obtained from stored stock of infected RBCs and of B. microti were obtained from infected patients during diagnosis. The ODT technique was applied to analyze and characterize detailed differences between P. falciparum and B. microti ring stage at the single cell level. Based on 3D quantitative information, accurate measurement was performed of morphological, biochemical, and biophysical parameters. Accurate measurements of morphological parameter ....

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Exploration of the ocular surface infection by SARS-CoV-2 and implications for corneal donation: An ex vivo study

Corantin Maurin and colleagues investigate the capacity of human cornea to be infected by SARS-CoV-2 virus and evidence for viral detection in corneas from donors with a positive test for SARS-CoV-2 infection. ....

Eteläuomen Läi , United States , France General , University Hospital , Saint Etienne , Pasteur Institute , Haute Normandie , James Chodosh , Josselin Rigaill , Estelle Audoux , Nora Mallouk , Les Ulis , Cyrille Haddar , Corneamax Eurobio , University Hospital Of Nantes , Harvard Medical School , Graphpad Prism Software , Thermo Fisher , University Hospital Of Saint Etienne , Jean Monnet University , Sigma Aldrich , French Eye Bank , Zymo Research , Severe Acute Respiratory Syndrome Coronavirus , Coronavirus Disease , Creative Commons Attribution License ,