Stay updated with breaking news from Led Eng. Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.
February 27, 2024 The start of the local 2024 election season is nearly here. There are many important state and local races and a critical measure on the ballot. Here are Los Cerritos Community News' recommendations: Linda Sanchez for 38th Congressional District From COVID to garnering tens of millions of dollars for critical local infrastructure…
SARS-CoV-2 variants with multiple spike mutations enable increased transmission and antibody resistance. Here, we combine cryo-EM, binding and computational analyses to study variant spikes, including one that was involved in transmission between minks and humans, and others that originated and spread in human populations. All variants showed increased ACE2 receptor binding and increased propensity for RBD up states. While adaptation to mink resulted in spike destabilization, the B.1.1.7 (UK) spike balanced stabilizing and destabilizing mutations. A local destabilizing effect of the RBD E484K ...