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Based on PCR melting curve method, this kit is used in detecting the copy number of SMN1 at the 7th exon and (or) the 8th exon in human genomic DNA.
Autophagy modulation or AHR activation affects the expression of epidermal differentiation-related markers in both in vitro and ex vivo psoriatic models.
Nanobubble ozone stored in hyaluronic acid decorated liposomes: antibacterial, anti-sars-cov-2 effect & biocompatibility tests
Chronic lymphocytic leukemia (CLL) has experienced a clinical revolution thanks to the discovery of crucial pathogenetic mechanisms. CLL is still an incurable disease due to intrinsic or acquired resistance of the leukemic clone. Venetoclax is a Bcl-2 inhibitor with a marked activity in CLL, but emerging patterns of resistance are being described. We hypothesize that intrinsic features of CLL cells may contribute to drive mechanisms of resistance to venetoclax. We analyzed the expression of IRF4, Notch2 and Mcl-1 in a cohort of CLL patients. We evaluated CLL cells viability after genetic and p...
Abstract The compelling need to provide adoptive cell therapy (ACT) to an increasing number of oncology patients within a meaningful therapeutic window makes the development of an efficient, fast, versatile, and safe genetic tool for creating recombinant T cells indispensable. In this study, we used nonintegrating minimally sized DNA vectors with an enhanced capability of generating genetically modified cells, and we demonstrate that they can be efficiently used to engineer human T lymphocytes. This vector platform contains no viral components and is capable of replicating extrachromosomally ...