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Asundexian Phase 3 AF Study Halted for Lack of Efficacy

The phase 3 OCEANIC-AF trial of the factor XI inhibitor asundexian (Bayer) has been stopped early owing to inferior efficacy vs apixaban in preventing stroke and systemic embolism in patients with AF. ....

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DOAC Cuts Stroke Risk From Subclinical Afib

But whether the small absolute gain shown in ARTESiA is worth the bleeds is another question ....

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Impressive Bleeding Profile With Factor XI Inhibitor in AF

Further details from the phase 2b AZALEA trial of the factor XI inhibitor abelacimab show significant reductions in major and clinically relevant nonmajor bleeding vs rivaroxaban for patients with AF. ....

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Judge allows one final amendment of class action suit over Fabrazyme prescription drug shortage

PITTSBURGH – A federal judge has granted a final opportunity to amend a class action complaint, for plaintiffs who claimed significant harm was sustained on behalf of themselves and/or their loved ones, based on a shortage of a pharmaceutical drug named Fabrazyme that began in 2009 and lasted until 2012. ....

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