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Essential process for SARS-CoV-2 viral replication visualized

During the replication of the SARS-CoV-2 virus, a long string of connected proteins is cleaved apart into individual proteins. This process is interrupted by an FDA-approved drug to treat COVID-19; however, the mechanistic details of this cleavage process are still unclear. Now, a team led by researchers at Penn State have produced the most detailed images to date of this process. ....

United States , National Institutes Of Health , Manju Narwal , Thomas Edwards , Jean Paul Armache , Katsuhiko Murakami , National Cancer Institute Facility In Frederick , National Cancer Institute Facility , Penn State , Biological Chemistry , Penn State Huck Institutes , Life Science , National Cancer Institute , National Institutes ,

Penn State University: Repurposing FDA-approved drugs may help combat COVID-19

Several FDA-approved drugs including for type 2 diabetes, hepatitis C and HIV significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. Specifically ....

Evaj Pell , Katsuhiko Murakami , Joyce Jose , Anoop Narayanan , Manju Narwal , Communications Biology , Laboratory For Advanced Biological Research At Penn , Penn State , Advanced Biological Research ,