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Intravenous Vitamin C for Patients Hospitalized With COVID-19

Two randomized clinical trials were harmonized to compare the effect of vitamin C vs control on outcomes in hospitalized patients with COVID-19 who were critica ....

Canada , United-states , Australia , Sunnybrook , Alberta , New-delhi , Delhi , India , Saudi-arabia , Bangkok , Krung-thep-mahanakhon , Thailand

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial examines the effect of initiation of a renin-angiotensin system inhibitor (ACE inhibitor or an angiotensin receptor blocker) on t ....

Helsinki , Eteläuomen-läi , Finland , Italy , Saudi-arabia , Toronto , Ontario , Canada , Colombo , Western , Sri-lanka , Australia

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial | Critical Care Medicine | JAMA

This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-te ....

United-kingdom , Nepal , India , Monash , South-australia , Australia , Saclay , France-general , France , Bristol , City-of , Paris

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial assesses the effect of treatment with an antiplatelet agent vs no antiplatelet therapy on days alive and free of intensive care u ....

Willebrand , Nordrhein-westfalen , Germany , Italy , Bristol , City-of , United-kingdom , Saclay , France-general , France , Australia , Paris