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Allergies are one of the most common health conditions in the world that affect 10 to 20% of Koreans. Although the disorder is accompanied by mild symptoms, it can lead to anaphylaxis, which is a severe and potentially life-threatening hypersensitivi
tmrFebruary 15, 2021 Antibody Isotyping Kit: Introduction Antibody is a blood protein produced in response to a specific antigen. An antibody is also known as immunoglobulin and is generally Y-shaped in structure. Advances in genetic engineering make antibodies, especially monoclonal antibodies, more robust and efficacious as these increase the binding capacity to any type of specific antigen and hence these are very effective as a diagnostics tool to evaluate various infectious diseases. Antibody isotyping kits are used to determine the class of monoclonal antibody and subclass identity. For...
E-Mail IMAGE: From left to right, Prof. Sang Woo Seo, Dr. Jina Yang, Mr. Yong Hee Han view more Credit: Seoul National University On Feb 5th, Seoul National University, College of Engineering (Dean Kookheon Char) announced that Professor Sang Woo Seo's research team (Dr. Jina Yang and Mr. Yong Hee Han (graduate student)) at School of Chemical and Biological Engineering has developed a synthetic protein quality control system to enhance full-length translation in bacteria. This technology is expected to increase the efficiency of the production of biopharmaceuticals, industrial enz...
Abstract Cancer immunotherapy with 4-1BB agonists has limited further clinical development because of dose-limiting toxicity. Here, we developed a bispecific antibody (bsAb; B7-H3×4-1BB), targeting human B7-H3 (hB7-H3) and mouse or human 4-1BB, to restrict the 4-1BB stimulation in tumors. B7-H3×m4-1BB elicited a 4-1BB–dependent antitumor response in hB7-H3–overexpressing tumor models without systemic toxicity. BsAb primarily targets CD8 T cells in the tumor and increases their proliferation and cytokine production. Among the CD8 T cell population in the tumor, 4-1BB is solely expressed ...