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 E-Mail Loss of smell, or anosmia, is one of the earliest and most commonly reported symptoms of COVID-19. But the mechanisms involved had yet to be clarified. Scientists from the Institut Pasteur, the CNRS, Inserm, Université de Paris and the Paris Public Hospital Network (AP-HP) determined the mechanisms involved in the loss of smell in patients infected with SARS-CoV-2 at different stages of the disease. They discovered that SARS-CoV-2 infects sensory neurons and causes persistent epithelial and olfactory nervous system inflammation. Furthermore, in some patients with persistent clinical...

Updated Jan 11, 2021 | 14:26 IST The Black Box helps investigators study the causes of crashes and suggest changes in flight engineering and policies. But the history of how a Black Box was invented is a juicy tale of research and enterprise. The Black Box is a cockpit voice recorder and a flight data recorder  |  Photo Credit: iStock Images Key Highlights The Black Box is not black and it is not one box. Here are juicy details about the orange-coloured device. If you love reading about interesting facts in history that led to major inventions and progress o...

22 Dec 2020 Many people with Alzheimer’s wake up frequently at night, nap excessively during the day, and lose their sense of time. Besides sleep cycles, the circadian clock also controls astrocyte and microglia activation, and knocking out one of the core clock genes, Bmal1, hastens plaque formation and promotes neuroinflammation and synaptic damage. Now, researchers led by Erik Musiek and Brian Lananna at Washington University in St. Louis report that Bmal1 regulates the gene for YKL-40, a marker of Alzheimer’s disease. Further, deleting the YKL-40 gene, Chi3l1, alters glial inflammator...

Imbalance in Gut Microbiome Can Lead to Depressive-Like Behaviors December 14, 2020 Share Researchers from the Institut Pasteur, Inserm, and the French National Centre for Scientific Research (CNRS) recently conducted a study “Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system” showing that an imbalance in the gut bacterial community can cause a reduction in some metabolites, resulting in depressive-like behaviors. These findings, which show that a healthy gut microbiota contributes to normal brain function, were published in Nature Co...

Depression is a mental disorder that affects more than 264 million people of all ages worldwide. Understanding its mechanisms is vital for the development of effective therapeutic strategies.