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RGI-2001 Plus Tacrolimus/Methotrexate Demonstrates Protective Effect From Acute GVHD Post Allo-HSCT

Prophylactic treatment with RGI-2001 plus tacrolimus and methotrexate led to a lower incidence of acute GVHD vs CIBMTR control following allo-HSCT.

Calvink-lee , Pfizer , Aacr-annual-meeting , Rgi-2001 , Tacrolimus , Methotrexate , Hematologic-oncology , Phase-2b-rgi-2001-301-trial-nct04014790- ,

Methotrexate, Leflunomide Treatment Associated With Increased Possibility of Adverse Pregnancy Outcomes in Patients With RA

Pregnant female patients with rheumatoid arthritis (RA) treated with methotrexate and leflunomide within 3 months of conception faced an increased possibility of adverse pregnancy outcomes, specifically stillbirth or abortion.

Korean-national-health-insurance , Image-credit , Autoimmune , Rheumatoid-arthritis , Methotrexate , Leflunomide , Adverse-pregnancy-outcomes ,

Methotrexate—but Not Glucocorticoids—Affects BMD in Patients With ALL

The findings add complexity to questions about the long-term impact of acute lymphoblastic leukemia (ALL) therapy.

Pediatric-pharmacology , Image-credit , New-africa , Methotrexate , Bmd , Bone-mineral-density ,

Most Effective Atopic Dermatitis Treatments May Pose Greatest Risk of Adverse Events

These findings, to be presented at AAAAI, may allow for greater awareness among clinicians when prescribing eczema therapies.

United-states , American , Alexandro-chu , Lawrence-eichenfield , American-academy-of-allergy , Annual-meeting , Eczema , Atopic-dermatitis , Abrocitinib , Methotrexate , Corticosteroids , Risk

World Cancer Day 2024: Yellapragada Subbarow: How one Indian revolutionised cancer treatment

World Cancer Day: World Cancer Day is a global observance dedicated to raising awareness about cancer, encouraging its prevention, detection, and treatment, and highlighting the need for increased support in the battle against this formidable disease. Marked on February 4th each year, World Cancer Day unites individuals, communities, and organisations worldwide in the common goal of addressing the challenges posed by cancer and working towards a future where its impact is significantly reduced.

Madras , Tamil-nadu , India , Benjamin-minge-duggar , Yellapragada-subbarao , Yellapragada-subbarow , Madras-medical-college , World-cancer-day , Lederle-laboratories , World-cancer-day-2024 , Cancer

Eingun James Song, MD: Tips, Tricks for Dermatologists Treating Palmoplantar Psoriasis

In this discussion with E. James Song, MD, several unique clinical pearls for those in dermatology were described and had been drawn from Song’s Winter Clinical presentation.

Hawaii , United-states , Eingun-james-song , Frontier-dermatology , Therapeutic-pearls , Clinical-dermatology-conference , Psoriasis , Winter-clinical , Palmoplantar , Acitretin , Cyclosporine

Clinical Challenges: Secondary CNS Relapse in Diffuse Large B-Cell Lymphoma

Questions remain on how best to diagnose and treat CNS involvement in high-risk groups

University-of-pennsylvania , Pennsylvania , United-states , Delaware , Philadelphia , New-york , Joshua-brody , Leah-lawrence , Jakub-svoboda , International-prognostic-index , Tisch-cancer-institute-at-mount-sinai , Perelman-school-of-medicine

#VisualAbstract: Methotrexate alleviates pain among patients with hand osteoarthritis and concurrent synovitis

1. Methotrexate 20 mg once weekly resulted in significant pain reduction among patients with hand osteoarthritis of the inflammatory phenotype. 2. Adverse events in the treatment group were comparable to the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: Hand osteoarthritis is a debilitating condition with limited treatment options. Topical therapy, oral analgesics, and non-pharmacological therapy

Australia , Minute-medicine-inc , Rating-level , Active-rheumatoid-arthritis , Between-nov , Hand-osteoarthritis , Methotrexate , Osteoarthritis , Osteoarthritis-pain , Pain , Synovitis

Methotrexate alleviates pain among patients with hand osteoarthritis and concurrent synovitis

1. Methotrexate 20 mg once weekly resulted in significant pain reduction among patients with hand osteoarthritis of the inflammatory phenotype. 2. Adverse events in the treatment group were comparable to the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: Hand osteoarthritis is a debilitating condition with limited treatment options. Topical therapy, oral analgesics, and

Australia , Rating-level , Active-rheumatoid-arthritis , Between-nov , Hand-osteoarthritis , Methotrexate , Musculoskeletal-pain , Osteoarthritis , Rheumatology , Synovitis , Chronic-disease

Network Meta-Analysis Validates the Use of Methotrexate in RA Compared With Other Treatments

A network meta-analysis confirmed the efficacy of methotrexate for patients with rheumatoid arthritis (RA) and validated it as the primary reference conventional synthetic disease-modifying antirheumatic drug for treatment in this population.

Digital-health , Population-health , Women-health , Autoimmune , Meta-analysis , Methotrexate , Rheumatoid-arthritis , Ra , Csdmard , Tdmard , Disease-modifying-drug