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Damaged mitochondria activate autoimmunity suggests genome study Appeared in BioNews 1095 Accumulation of defective mitochondria in cells may contribute to autoimmune conditions, such as Sjögren s syndrome, according to a recent study. Researchers showed that mice lacking the IRGM1gene showed similar autoimmune symptoms to patients with Sjögren s syndrome because they were not able to properly recycle their mitochondria. This left damaged parts of mitochondria in the cells, triggering an immune response against them. Many autoimmune diseases exhibit increased type 1 interferon, said Dr Michael Fessler, senior author and head of the immunity, inflammation, and disease laboratory at the US National Institute of Environmental Health Sciences (NIEHS) in North Carolina. Our studies show how mitochondrial DNA that is not removed activates the immune system in mice and how it may happen in humans. ....
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