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ReliaPrep™ gDNA Tissue Miniprep (100 & 250 prep) from Promega Corp.

Read independent reviews on ReliaPrep™ gDNA Tissue Miniprep (100 & 250 prep) from Promega Corp. on SelectScience ....

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Frontiers | Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior

In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited. To further investigate this subject, we used the model of tilapia lake virus (TiLV) infection of zebrafish (Danio rerio), which was previously developed in our laboratory. We demonstrated that TiLV persists in the brain of adult zebrafish for at least 90 days, even when the virus is not detectable in other peripheral organs. The virions were found in the whole brain. During TiLV infection, zebrafish displayed a clear sickness behavior: decreased locomotor activity, reduced food intake, and primarily localizes near the bottom zone of aquaria. Moreover, during swimming individual fish exhibited also unusual spiral movement patterns. Gene expression study revealed that TiLV induces in the brain of adult fish strong anti-viral and inflammatory response and up-regulates ....

United States , Baden Wüberg , Noord Brabant , Novoab Nodavirus , Albert Willemsen Noldus , Oreochromis Niloticus , Oncorhynchus Mykiss , Le Clerc , Clin Microbiol , Pons Garcia , Carassius Auratus , Calcarifer Bloch , Gen Virol , Weissella Cibaria , Kembou Tsofack , Carlos Kreutz , Gray Oreochromis Niloticus , Anim Health Res Rev , Microglia In Development , Jagiellonian University In Krakow , Priority Research Area Bio , Kinga Sawa Jagiellonian University , Zebrafish Models For Translational Neuroscience Research , Research University , Ethics Committee In Krak , Excellence Initiative ,

[Full text] CPNE1 Enhances Colorectal Cancer Cell Growth, Glycolysis, and Drug Res


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1Department of General Surgery, Shanghai Eighth People’s Hospital, Jiangsu University, Shanghai, People’s Republic of China;
2Department of General Surgery, Shanghai Eighth People’s Hospital, Shanghai, People’s Republic of China;
3Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
These authors contributed equally to this work
Correspondence: Shengli Pan; Xianju Qin
Department of General Surgery, Shanghai Eighth People’s Hospital, Caobao Road No. 8, Shanghai 200232, People’s Republic of China
Tel +86-21-34284588
Introduction: Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. Copines-1 (CPNE1) has been shown to be overexpressed in various cancers; however, the role of CPNE1 in CRC remains unknown. Therefore, it is of great importance to elucidate the role of CPNE1 in CRC and its underlying mechanism of action. ....

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