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The current study investigates the therapeutic and optical properties of bismuth oxide (Bi2O3) particles for selective melanoma therapy and prevention. The Bi2O3 particles were prepared using a standard precipitation method. The Bi2O3 particles induced apoptosis in human A375 melanoma cells but not human HaCaT keratinocytes or CCD-1090Sk fibroblast cells. This selective apoptosis appears to be associated with a combination of factors: increased particle internalization (2.29 ± 0.41, 1.16 ± 0.08 and 1.66 ± 0.22-fold of control) and enhanced production of reactive oxygen species (ROS) (3.4 ± 0.1, 1.1 ± 0.1 and 2.05 ± 0.17-fold of control) in A375 cells compared to HaCaT and CCD-1090SK cells, respectively. As a high-Z element, bismuth is also an excellent contrast agent for computer tomography, which renders Bi2O3 a theranostic material. Moreover, Bi2O3 displays high UV absorption and low photocatalytic activity compared to other semiconducting metal oxides, which opens further pote ....
VANCOUVER, British Columbia, May 01, 2023 Zymeworks Inc. , a clinical-stage biotechnology company developing novel, multifunctional biotherapeutics, today announced that management will. | May 1, 2023 ....
Zymeworks Inc. , a clinical-stage biotechnology company developing novel, multifunctional biotherapeutics, today announced that management will report its first quarter 2023 financial results after. | April 17, 2023 ....
Zymeworks Inc. , a clinical-stage biotechnology company developing novel, multifunctional biotherapeutics, today announced that management will participate in the following upcoming investor. | April 3, 2023 ....