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Astronomy meets pathology to identify predictive biomarkers for cancer immunotherapy

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IMAGE: The AstroPath platform allows for the assessment of the level of expression of a given marker on individual cells, while maintaining information on their spatial location. Shown here is.
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Credit: Seyoun Park, Ph.D.
Pairing sky-mapping algorithms with advanced immunofluorescence imaging of cancer biopsies, researchers at The Mark Foundation Center for Advanced Genomics and Imaging at Johns Hopkins University and the Bloomberg~Kimmel Institute for Cancer Immunotherapy developed a robust platform to guide immunotherapy by predicting which cancers will respond to specific therapies targeting the immune system.
A new platform, called AstroPath, melds astronomic image analysis and mapping with pathology specimens to analyze microscopic images of tumors. ....

United States , Janis Taube , Charles Roberts , Evanj Lipson , Richard Wilton , Shlomit Jessel , Harriet Kluger , Evan Lipson , Inbalb Sander , Peter Nguyen , Jose Loyola , Qingfeng Zhu , Akoya Biosciences , Michele Cleary , Robert Anders , Suzannel Topalian , Elizabethm Jaffee , Ludmila Danilova , Elizabeth Engle , Margaret Eminizer , Daphne Wang , Sneha Berry , Aleksandra Ogurtsova , Angelo Demarzo , Haiying Xu , Roberta Anders ,

Markey Study Shows Kentucky Endometrial Cancer Patients Have Higher Rates of DACH1 Mutation

A new study by Markey researchers shows a higher-than-average rate of DACH1 mutations in Kentucky patients with endometrial cancer.
LEXINGTON, Ky. (Jan. 12, 2020) A new study by University of Kentucky Markey Cancer Center researchers shows that DACH1 mutations are prevalent in Kentucky patients with endometrial cancer, suggesting that DACH1 may be a candidate biomarker for future trials with immunotherapy.
DACH1 is a transcriptional repressor and tumor suppressor gene that is frequently mutated in other cancers, including melanoma, bladder and prostate cancer. The loss of DACH1 expression is also associated with poor prognosis and reduced survival in women with uterine cancer.
Published in PLOS One, the study sought to determine the frequency of DACH1 mutations in patients with endometrial cancer in Kentucky. Using the Oncology Research Information Exchange Network (ORIEN), a personalized medicine consortium that Markey joined in 2017, researchers examined clinical ....

United States , Jill Kolesar , United Kingdom Markey Cancer Center , University Of Kentucky Markey Cancer Center , Oncology Research Information Exchange Network , National Cancer Institute Genome Atlas , Cancer Center Support Grant , Kentucky Markey Cancer Center , National Cancer Institute , Cancer Genome Atlas , Cancer Genome , Precision Medicine Clinic , Center Support Grant , ஒன்றுபட்டது மாநிலங்களில் , ஜில் க்கோளெசார் , ஒன்றுபட்டது கிஂக்டம் மார்‌க் புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் கெந்‌டகீ மார்‌க் புற்றுநோய் மையம் , புற்றுநோயியல் ஆராய்ச்சி தகவல் பரிமாற்றம் வலைப்பின்னல் , தேசிய புற்றுநோய் நிறுவனம் மரபணு அட்லஸ் , புற்றுநோய் மையம் ஆதரவு மானியம் , கெந்‌டகீ மார்‌க் புற்றுநோய் மையம் , தேசிய புற்றுநோய் நிறுவனம் , புற்றுநோய் மரபணு அட்லஸ் , புற்றுநோய் மரபணு , ப்ரிஸிஶந் மருந்து சிகிச்சையகம் , மையம் ஆதரவு மானியம் ,