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Markey Study Shows Kentucky Endometrial Cancer Patients Have Higher Rates of DACH1 Mutation


A new study by Markey researchers shows a higher-than-average rate of DACH1 mutations in Kentucky patients with endometrial cancer.
LEXINGTON, Ky. (Jan. 12, 2020)  A new study by University of Kentucky Markey Cancer Center researchers shows that DACH1 mutations are prevalent in Kentucky patients with endometrial cancer, suggesting that DACH1 may be a candidate biomarker for future trials with immunotherapy.
DACH1 is a transcriptional repressor and tumor suppressor gene that is frequently mutated in other cancers, including melanoma, bladder and prostate cancer. The loss of DACH1 expression is also associated with poor prognosis and reduced survival in women with uterine cancer.
Published in PLOS One, the study sought to determine the frequency of DACH1 mutations in patients with endometrial cancer in Kentucky. Using the Oncology Research Information Exchange Network (ORIEN), a personalized medicine consortium that Markey joined in 2017, researchers examined clinical ....

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UK Study Provides Evidence for a 7-Day Quarantine for University Students Exposed to COVID-19


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LEXINGTON, Ky. (Dec. 17, 2020) A new University of Kentucky study provides direct evidence for a testing strategy that could be used to support a shortened period of quarantine for university students who are exposed to the virus but are asymptomatic. The study is now available on the preprint server medRxiv and is pending journal review.
Working with UK Health Corps, researchers in the study enrolled 101 asymptomatic students in quarantine following COVID-19 exposure, and 90 students completed surveys and testing. Nasopharyngeal swabs for COVID-19 were given to the students on days three or four, five, seven, 10 and 14 of their quarantine.
Of the 90, 14 (16%) had at least one positive test while in quarantine, but no eligible students received an initial positive test on day 10 or 14. In this study, all eligible students who developed a COVID-19 infection were positive by day seven post-exposure. ....

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