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Frontiers | Importance of Diagnostic Accuracy in Big Data: False-Positive Diagnoses of Type 2 Diabetes in Health Insurance Claims Data of 70 Million Germans

Large data sets comprising diagnoses about chronic conditions are becoming increasingly available for research purposes. In Germany, it is planned that aggregated claims data including medical diagnoses from the statutory health insurance with roughly 70 million insurants will be published on a regular basis. Validity of the diagnoses in such big data sets can hardly be assessed. In case the data set comprises prevalence, incidence and mortality, it is possible to estimate the proportion of false positive diagnoses using mathematical relations from the illness-death model. We apply the method to age-specific aggregated claims data from 70 million Germans about type 2 diabetes in Germany stratified by sex and report the findings in terms of the ratio of false positive diagnoses of type 2 diabetes (FPR) in the data set. The age-specific FPR for men and women changes with age. In men, the FPR increases linearly from 1 to 3 per mil in the age 30 to 50. For ages between 50 to 80 years, FPR remains below 4 per mil. After 80 years of age, we have an increase to about 5 per mil. In women, we find a steep increase from age 30 to 60, the peak FPR is reached at about 12 per mil between 60 and 70 years of age. After age 70, the FPR of women drops tremendously. In all age-groups, the FPR is higher in women than in men. In terms of absolute numbers, we find that there are 217 thousand people with a false-positive diagnosis in the data set (95% confidence interval, CI: 204 to 229), the vast majority women (172 thousand, 95% CI: 162 to 180). Our work indicates that possible false positive (and negative) diagnoses should appropriately be dealt with in claims data, e.g., by inclusion of age- and sex-specific error terms in statistical models, to avoid potentially biased or wrong conclusions.

Germany , Berlin , German , Germans , Robert-koch-institut , Ihlep-bergh , Digitale-medizin , Van-vlymen , Schulz-mandy , Centers-for-disease , National-health , National-center

Detailed text transcripts for TV channel - MSNBC - 20180326:13:30:00

horrific mall fire in the siberian city yesterday. russian officials say the blaze began on the fourth floor of the mall right by a children's entertainment room. 64 people died including children and at least 16 others are still missing. attorneys for the pulse nightclub shooter's widow will begin to present their case in court this morning. prosecutors say norah salman knew her husband was plan the attack. 49 people were killed in the massacre. the oldest gunmaker in the united states remington has filed for bankruptcy. remington outdoors says 2017 sales fell more than 30% year over year to $600 million. new data released from the national health and nutrition examination survey shows, listen to this, 40% of american adults were obese in 2015 and 2016. nutritionists and other experts say lifestyle, genetics and poor diet are old factors that led americans having a mass body

People , Russian , Children , Others , Mall , Blaze , Floor , Horrific-mall-fire , Entertainment-room- , Siberian-city , Officials , 16

Detailed text transcripts for TV channel - KNTV - 20101007:00:50:30

Detailed text transcripts for TV channel - KNTV - 20101007:00:50:30
vimarsana.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from vimarsana.com Daily Mail and Mail on Sunday newspapers.

People , Risk , Heart-attacks , Workplace , Heart-disease , Chest-pains , Noise , Who-don-t , National-health-and-nutrition-examination-survey , No-one , Occupations , Newsroom