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Obesity is associated with an increased risk for a broad spectrum of tumors, including colon cancer. And once cancer develops, statistics show that overweight or obese individuals are at higher risk of cancer recurrence and have a decreased chance of survival. The underlying mechanisms for this are unclear.
One of the emerging possibilities with regard to colon cancer is that excess lipids ­ a class of organic compounds, including fats, that are insoluble in water accumulate in both the fat-storing and non-fat-storing tissues of obese individuals. These intracellular lipids are stored in droplets (LDs) and are seen at higher volumes in colonic tumors relative to normal tissues. It is theorized that these droplets not only drive inflammation in the colonic epithelium, but they could also be the energy source that drives colon tumor formation and growth. ....

State Of Louisiana , United States , New Orleans , Suzana Savkovic , Louisiana Cancer Research Center , National Cancer Institute , Biospecimen Laboratory , Tulane Cancer Center , Biospecimen Core Laboratory , Greater New Orleans , Cancer Crusader , Next Generation Sequence Analysis Core , நிலை ஆஃப் லூசியானா , ஒன்றுபட்டது மாநிலங்களில் , புதியது ஆர்லீயந்ஸ் , லூசியானா புற்றுநோய் ஆராய்ச்சி மையம் , தேசிய புற்றுநோய் நிறுவனம் , துலேன் புற்றுநோய் மையம் , அதிகமானது புதியது ஆர்லீயந்ஸ் , புற்றுநோய் சிலுவைப்பான் ,