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The National Institutes of Health, which has been in the spotlight for its connections to the infamous Wuhan Institute of Virology, is the single largest funder for biomedical research globally, with a budget exceeding $40 billion in 2020. ....
Date Time Ludwig Johns Hopkins researchers develop new DNA detection method to improve liquid biopsies May 6, 2021, NEW YORK – A team of researchers at the Ludwig Center at Johns Hopkins has developed a far more sensitive and accurate next-generation gene sequencing technology for the detection of rare fragments of mutated DNA shed by tumors into body fluids. The detection of such DNA fragments-commonly referred to as “liquid biopsies”-holds the promise of easing the detection of cancers at their earliest stages, when they are most likely to be curable. In a study led by Ludwig Johns Hopkins researchers Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos and MD-PhD student Joshua Cohen and published May 3 in Nature Biotechnology, the team reported the development and analytical assessment of SaferSeqS (for “Safer Sequencing System”). Their report shows that SaferSeqS is a major improvement over a now widely adopted method developed at Ludwig Johns Hop ....
E-Mail IMAGE: New SaferSeqS technology detects rare mutations in blood in a highly efficient manner and reduces the error rate. view more Credit: Elizabeth Cooke Next-generation gene sequencing (NGS) technologies in which millions of DNA molecules are simultaneously but individually analyzed theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream. Identifying such mutations enables earlier diagnosis of cancer and can inform treatment decisions. Johns Hopkins Kimmel Cancer Center researchers developed a new technology to overcome the inefficiencies and high error rates common among next-generation sequencing techniques that have previously limited their clinical application. To correct for these sequencing errors, the research team from the Ludwig Center and Lustgarten Laboratory at the Johns Hopkins Kimmel Cancer Center developed SaferSeqS (Safer Sequencing System), a major improvement ....