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Objective To identify the optimal dose and modality of exercise for treating major depressive disorder, compared with psychotherapy, antidepressants, and control conditions. Design Systematic review and network meta-analysis. Methods Screening, data extraction, coding, and risk of bias assessment were performed independently and in duplicate. Bayesian arm based, multilevel network meta-analyses were performed for the primary analyses. Quality of the evidence for each arm was graded using the confidence in network meta-analysis (CINeMA) online tool. Data sources Cochrane Library, Medline, Embas...

Objective To identify the availability of results for trials registered on the European Union Clinical Trials Register (EUCTR) compared with other dissemination routes to understand its value as a results repository. Design Cross sectional audit study. Setting EUCTR protocols and results sections, data extracted 1-3 December 2020. Population Random sample of 500 trials registered on EUCTR with a completion date of more than two years from the beginning of searches (ie, 1 December 2018). Main outcome measures Proportion of trials with results across the examined dissemination routes (EUCTR, C...

Ali Sié and colleagues present pre-specified anthropometric outcomes from a randomized controlled trial that assessed the impact of a single-dose of oral azithromycin on infant mortality in Burkina Faso.

Gattrell and colleagues developed the ACCORD reporting guideline to guide the reporting of biomedical studies using consensus methods.

Many researchers support open science, but how can they translate this view into behaviours to boost sharing? Many researchers support open science, but how can they translate this view into behaviours to boost sharing?