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Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

Researchers explored how Death Induced by Survival gene Elimination through the analysis of RNA-induced silencing complex-bound short RNAs in Alzheimer's disease models influences neuronal survival and correlates with neurotoxicity in AD. ....

Nature Communications , Death Induced , Amyloid Beta , Amyotrophic Lateral Sclerosis , Alzheimer 39s Disease , Ell Death , Dna Damage , Ene Expression , Neurodegenerative Diseases , Ibonucleic Acid , Rna Interference , Tau Protein ,

Treatment Strategies Using Radiotherapy or Other Locoregional Approaches in Desmoid Tumors

Chandrajit Raut, MD, explores the role of radiotherapy and other locoregional strategies in desmoid tumor management, highlighting the emerging role of cryoablation and HIFU. ....

Chandrajit Raut , Desmoid Tumors , Peer Exchange , Systemic Therapy , Fda Approval , Defi Study ,

CGRP antagonists and dietary changes show promise for migraine treatment

Review in "Medicina" explores advancements in migraine therapy, highlighting the role of CGRP antagonists and dietary interventions like ketogenic and low-glycemic diets in reducing migraine frequency and severity. ....

City Of , United Kingdom , International Classification Of Headache Disorders , International Headache Society , World Health Organization , International Classification Of Diseases , Ketogenic Diet , Image Credit , Headache Disorders , Sick Children , Dietary Approaches , Stop Hypertension , Ketogenic Diet , Monoclonal Antibody , Physical Activity ,

"Direct-to-consumer tests advertised online in Australia and their impl" by Patti Shih, Pauline Ding et al.

OBJECTIVES: The objective of this study is to map the range and variety of direct-to-consumer (DTC) tests advertised online in Australia and analyse their potential clinical utility and implications for medical overuse. DESIGN: Systematic online search of DTC test products in Google and Google Shopping. DTC test advertisements data were collected and analysed to develop a typology of potential clinical utility of the tests at population level, assessing their potential benefits and harms using available evidence, informed by concepts of medical overuse. RESULTS: We identified 484 DTC tests (103 unique products), ranging from $A12.99 to $A1947 in cost (mean $A197.83; median $A148.50). Using our typology, we assigned the tests into one of four categories: tests with potential clinical utility (10.7%); tests with limited clinical utility (30.6%); non-evidence-based commercial 'health checks' (41.9%); and tests whose methods and/or target conditions are not recognised by the gene ....

Decision Making , Ealth Services Accessibility , Ealth Services Administration Management ,

New Omicron subvariants test vaccine limits, reveal unique infection challenges

Study reveals that the Omicron subvariants BA.2.86 and FLip show unique mutations and infectivity profiles, with BA.2.86 being highly infectious and resistant to most conventional antibodies, underscoring the need for updated vaccines. ....

Coronavirus Disease Covid 19 , Cell Line , Covid 19 , Next Generation , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Spike Protein ,