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Nemolizumab Therapy for Moderate-to-Severe Prurigo Nodularis

1. Nemolizumab may reduce inflammatory, neural, and epithelial signalling in patients with prurigo nodularis by inhibiting IL-31. 2. Nemolizumab may be an effective monoclonal antibody treatment for moderate-to-severe prurigo nodularis. Evidence Rating Level: 2 (Good) Study Rundown: Prurigo nodularis (PN) is a chronic inflammatory dermatosis characterized by hyperkeratotic nodules. PN often adversely affects the quality ....

United States , Minute Medicine Inc , Rating Level , Peak Pruritus Numerical Rating Scale , Prurigo Nodularis ,

Nemolizumab Led to Improvement in Neural, Inflammatory, Epithelial Signaling for Prurigo Nodularis

This new research indicates a potentially-promising new way of addressing clinical management of prurigo nodularis.
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United States , Shawng Kwatra , Shawn Kwatra , Valerie Julia , Peak Pruritus Numerical Rating Scale , Johns Hopkins University School , Epithelial Dysregulation , Patients With Moderate , Severe Prurigo Nodularis Treated With , Prurigo Nodularis ,

Dupilumab Outcomes Stable in Open-Label AD Study

Other recent research on the biologic has shown that it improves lesional skin barrier function and rapidly reduces the abundance of Staphylococcus aureus on lesional skin. ....

United States , Sanofi Genzyme , Alisa Beck , Andrew Blauvelt , National Institute Of Allergy , University Of Rochester , University Of Rochester Medical Center , Oregon Medical Research Center , Atopic Dermatitis Research Network , Revolutionizing Atopic Dermatitis , Rochester Medical Center , National Institute , Infectious Diseases , Eczema Area , Severity Index , Peak Pruritus Numerical Rating Scale , Atopic Dermatitis , Biologic Therapy , Clinical Research , Clinical Trials , Linical Studies , Topical Corticosteroids , Corneal Disease , Healthcare And Medical Technology , Ealth And Medical Tech , Ealth And Med Tech ,

Abrocitinib Improvements Sustained in AD Extension Study

In the analysis that stratified patients by age (18-50 and over 50 years), the sustained improvement with the JAK-1 selective inhibitor as monotherapy was seen regardless of age. ....

New York , United States , Northwestern University , Andrewf Alexis , Abrocitinib Cibinqo , Raj Chovatiya , Weill Cornell Medical College , Revolutionizing Atopic Dermatitis , Eczema Area , Severity Index , Global Assessment , Peak Pruritus Numerical Rating Scale , Dermatology Life Quality Index , Atopic Dermatitis , Clinical Research , Clinical Trials , Linical Studies , Healthcare And Medical Technology , Ealth And Medical Tech , Ealth And Med Tech , Ealth And Medical Technology , Adolescent Medicine , Preventive Screening , Quality Of Life , Ealth Related Quality Of Life , Severity Indices ,

Two Biologics Evaluated for Facial, Hand, Foot Dermatitis

Lebrikizumab was efficacious in clearing and improving facial and hand dermatitis, burdensome and difficult-to-treat areas, in most patients, Dr Jenny Murase said, in reporting results at RAD 2023. ....

United States , Palo Alto , San Francisco , University Of Pennsylvania , Eric Simpson , Eli Lilly , Jennye Murase , Chiesa Fuxench , Zelma Chiesa Fuxench , Jonathani Silverberg , Palo Alto Calf Foundation Medical Group , American Academy Of Dermatology , George Washington University , Science University , Oregon Health , University Of California , European Union , Regeneron Pharmaceuticals , Drug Administration , Revolutionizing Atopic Dermatitis , Foundation Medical , New England Journal , Investigator Global Assessment , Peak Pruritus Numerical Rating Scale , Hand Eczema Questionnaire , American Academy ,