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Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells
The clinical phenotype of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences.
To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information.
The study, published as a preprint on the
bioRxiv server, uses a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable. ....

Liji Thomas , Image Credit , Sars Cov 2 , Stem Cells , Angiotensin Converting Enzyme 2 , Cell Membrane , Corona Virus , Genetic Information , Induced Pluripotent Stem Cells , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , படம் கடன் , தண்டு செல்கள் , செல் சவ்வு , கொரோனா வைரஸ் , ஜெநெடிக் தகவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study shows how m6A regulators influence metabolic heterogeneity of hepatocellular carcinoma

Study shows how m6A regulators influence metabolic heterogeneity of hepatocellular carcinoma
Cancer cells acquire growth advantages over normal cells in myriad ways. Changes in cell programming allow these cells to grow in an uncontrolled fashion, thereby forming the cancer mass.
Hepatocellular carcinoma (HCC), being highly malignant and invasive with a high recurrence rate and drug-resistant phenotype, is one of the most dreadful cancers. Understanding the underlying molecular mechanisms is crucial to design therapeutic interventions and to predict patient prognosis.
Cancer cells use metabolic, immunogenic, or growth-related strategies, which can be controlled by a number of alterations in the cell process. Of these, post-transcriptional RNA modification has recently sparked interest among cancer biologists. N6-methyladenosine (m6A) methylation, a type of RNA modification, remains the most abundant epigenetic (non-DNA related) modification in eukaryotic cells. ....

Lun Xiu Qin , Emily Henderson , Fudan University , International Cancer Genome Consortium , Cancer Biology , Cancer Genome Atlas , Hepatocellular Carcinoma , Liver Cancer , லூந் க்ஷிு குயின் , எமிலி ஹென்டர்சன் , சர்வதேச புற்றுநோய் மரபணு கூட்டமைப்பு , புற்றுநோய் உயிரியல் , புற்றுநோய் மரபணு அட்லஸ் , வளர்சிதை மாற்றம் , கல்லீரல் புற்றுநோய் , அறுவை சிகிச்சை ,

Live attenuated SARS-CoV-2 vaccine candidate shows protective efficacy in vivo

A new preprint on the bioRxiv server describes the development of a live attenuated vaccine candidate to counter the growing threat of the COVID-19 pandemic. ....

Liji Thomas , Coronavirus Disease Covid 19 , In Vivo , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Weight Loss , இல் விவோ , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , எடை இழப்பு ,

Study reveals genetic signature of colibactin implicated in the development colorectal cancers

Study reveals genetic signature of colibactin implicated in the development colorectal cancers
Escherichia coli bacteria are constitutive members of the human gut microbiota. However, some strains produce a genotoxin called colibactin, which is implicated in the development of colorectal cancer.
While it has been shown that colibactin leaves very specific changes in the DNA of host cells that can be detected in colorectal cancer cells, such cancers take many years to develop, leaving the actual process by which a normal cell becomes cancerous obscure.
The group of Thomas F. Meyer at the Max Planck Institute for Infection Biology in Berlin together with their collaborators have now been able to catch colibactin in the act of inducing genetic changes that are characteristic of colorectal cancer cells and cause a transformed phenotype - after only a few hours of infection. ....

Thomasf Meyer , Amina Iftekhar , Michael Sigal , Emily Henderson , University Hospital , Max Planck Institute For Infection Biology , Max Planck Institute , Infection Biology , E Coli , Colorectal Cancer , Growth Factor , Stem Cells , அமினா இப்தெகர் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் மருத்துவமனை , தொற்று உயிரியல் , ஏ கோலி , பெருங்குடல் புற்றுநோய் , வளர்ச்சி காரணி , தண்டு செல்கள் ,

Study highlights the epigenetics of life at high altitudes

Study highlights the epigenetics of life at high altitudes
Humans inhabit an incredible range of environments across the globe, from arid deserts to frozen tundra, tropical rainforests, and some of the highest peaks on Earth. Indigenous populations that have lived in these extreme environments for thousands of years have adapted to confront the unique challenges that they present.
Approximately 2% of people worldwide live permanently at high altitudes of over 2,500 meters (1.5 miles), where oxygen is sparse, UV radiation is high, and temperatures are low. Native Andeans, Tibetans, Mongolians, and Ethiopians exhibit adaptations that improve their ability to survive such conditions. Andeans, for example, display increased chest circumference, elevated oxygen saturation, and a low hypoxic ventilatory response, enabling them to thrive at exceptionally high elevations. ....

Cerro De Pasco , United States , Ainash Childebayeva , Emily Henderson , Cayetano Heredia University , Department Of Archaeogenetics , University Of Michigan , Genome Biology , Wide Epigenetic Signatures , Adaptive Developmental Plasticity , Peruvian Quechua , Andean Altiplano , Cerro De Pasco High Altitude , Max Planck Institute , Human History , Central Asia , Dna Methylation , சிஇஆர்ஆர்ஓ டி பாஸ்கோ , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , கேயேதானோ பரம்பரை பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் , மரபணு உயிரியல் , பரந்த எபிஜெனெடிக் கையொப்பங்கள் , பெருவியன் க்வ்ய்க்ஃப்வா , சிஇஆர்ஆர்ஓ டி பாஸ்கோ உயர் உயரம் ,