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Specific Telomere-targeting Therapy may be a Promising Treatment Against Cancer

Specific Telomere-targeting Therapy may be a Promising Treatment Against Cancer
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Elderly Esophageal Cancer Patients Receive Suboptimal Therapy

Elderly Esophageal Cancer Patients Receive Suboptimal Therapy
by Angela Mohan on
February 10, 2021 at 2:25 PM
Patients aged above 70 years with locally advanced esophageal (E) and esophagogastric junction (EGJ) cancer should be provided with optimal therapy that has the potential to cure, which includes initial chemoradiotherapy (NACR) and surgical resection.
According to researchers, this recommended therapy is often not offered to elderly patients out of concern that they will not tolerate such an intensive treatment regimen.
In a new study, they found that older patients who received the therapy had outcomes comparable with those of younger patients (under 70 years old).
Journal of the American College of Surgeons in advance of print. ....

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Knowing How Cancer Cells Avoid Defenses Open Gates for New Therapy

Knowing How Cancer Cells Avoid Defenses Open Gates for New Therapy
by Angela Mohan on
December 29, 2020 at 7:18 PM
Cancer Discovery.
Cells interpret these rogue bits of DNA as evidence of viral invaders, which sets off their internal alarm bells and leads to inflammation. Immune cells travel to the site of the tumor and churn out defensive chemicals. A mystery has been why this immune reaction, triggered by the cancer cells, does not spell their downfall.
The elephant in the room is that we didn t really understand how cancer cells were able to survive and thrive in this inflammatory environment, says Samuel Bakhoum, a physician-scientist at MSK and a member of the Human Oncology and Pathogenesis Program. ....

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