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Four year just joining us conversation is jackie alamani. tell me about this first overseas trip really placing vice president harris in the middle of the most vexing policy challenges that the last five american presidents haven't been able to make much progress on. >> thank you very much for having me. this is vice president kamala harris on the first foreign trip in guatemala and mexico late irtonight adds you noted. we are likely to see and already seeing a shift in tone than we saw in four years of trump and less drama, less bizarre and quite frankly offensive headlines in the trump admin...

Just... science. (man) i've made progresson with my mental health. so when i started having unintentional body movements called tardive dyskinesia... ... i ignored them. but when the movements in my hands and feet started throwing me off at work... i finally had to say, 'it's not ok.' it was time to talk to my doctor about austedo. she said that austedo helps reduce td movements in adults... ...while i continue with most of my mental health medications. (vo) austedo can cause depression, suicidal thoughts, or actions in patients with huntington's disease. pay close attention to and call your d...

A hug. it does seem like that is still on track, that it's -- the delay is not a question of things falling apart. it's more that they are optimistic enough about actually getting there that they want some more time to try and work it out. there are still some land mines to navigate. but i think that is something that we may still see progress on. the other things that we're talking about i think are broadly big picture falling back into a lot of the same patterns that we've seen all the way along. infrastructure, we were pretty optimistic about it a week ago, but now you have negotiations on ...

Read more about US Stocks extend losses on Wednesday on Business Standard. Meanwhile, declines accelerated in the wake of the policy statement from the Federal Reserve. The central bank kept overnight interest rate near zero and made no change to its monthly bond purchases, as was widely expected, and pledged to keep that