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Proof-of-Concept Program announces second year of funding to bring research to market

Proof-of-Concept Program announces second year of funding to bring research to market
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A nonviral, nonintegrating DNA nanovector platform for the safe, rapid, and persistent manufacture of recombinant T cells

Abstract
The compelling need to provide adoptive cell therapy (ACT) to an increasing number of oncology patients within a meaningful therapeutic window makes the development of an efficient, fast, versatile, and safe genetic tool for creating recombinant T cells indispensable. In this study, we used nonintegrating minimally sized DNA vectors with an enhanced capability of generating genetically modified cells, and we demonstrate that they can be efficiently used to engineer human T lymphocytes. This vector platform contains no viral components and is capable of replicating extrachromosomally in the nucleus of dividing cells, providing persistent transgene expression in human T cells without affecting their behavior and molecular integrity. We use this technology to provide a manufacturing protocol to quickly generate chimeric antigen receptor (CAR)–T cells at clinical scale in a closed system and demonstrate their enhanced anti-tumor activity in vitro and in vivo in comparis ....

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Amartus Wins MEF 3.0 PoC Business Impact Award for Remote Employee SASE Connectivity and Cloud Automation

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Amartus is the winner of the MEF 3.0 Proof of Concept Business Impact Award for its work with several partners on real-world Secure Access Service Edge (SASE) services. The award winners were announced on March 10, 2021.
SASE services address a real-world challenge of providing secure access to information and communications technology (ICT) services for entire workforces who find themselves having to quickly switch to Work From Home (WFH) due to Covid-19. Amartus worked in partnership with Sparkle, Nefeli Networks and Versa Networks to design, implement and showcase an integrated, end-to-end SASE solution using best in breed technologies and expert services to demonstrate what is possible. ....

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Juniper Networks Demonstrates Industry Leadership with Two MEF Proof of Concept Showcase Awards

Juniper Networks Demonstrates Industry Leadership with Two MEF Proof of Concept Showcase Awards
Juniper Paragon Automation™ Solutions Recognized by MEF for Helping Service Providers Deliver a Superior Service Experience
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SUNNYVALE, Calif., March 10, 2021 /PRNewswire/ Juniper Networks (NYSE: JNPR), a leader in secure, AI-driven networks, today announced its Juniper Paragon Automation™ solutions received top honors in the Q1 2021 MEF 3.0 Proof of Concept (PoC) Showcase. Juniper Paragon Active Assurance was recognized in two categories for its unique ability to help service providers deliver a superior quality of service experience, underscoring the market demand for modern automation solutions that embed active assurance to proactively identify and solve network problems before customers are impacted. ....

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Rowan researcher wins Science Center award for cornea repair innovation

Dr. Iman Noshadi is developing an ocular sealant for eye injuries and cornea tissue repair.
A Rowan University researcher has won an award from the University City Science Center’s Proof-of-Concept Program, which works with regional academic and research institutions to prepare their most promising life science and health care technologies for commercialization.
Dr. Iman Noshadi, a chemical engineering assistant professor in the Henry M. Rowan College of Engineering, is one of three awardees who will implement their proof-of-concept plans and award funding on their projects with assistance from the Science Center in Philadelphia. The other two awardees represent The Pennsylvania State University and Temple University. ....

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