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Study identifies SARS-CoV-2 spike conformation exposing potential new therapeutic targets Researchers in the United States have demonstrated that the viral spike protein used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect host cells adopts an open conformation exposing novel epitopes that could serve as targets for therapeutic strategies to protect against coronavirus disease 2019 (COVID-19). The currently approved COVID-19 vaccines and many clinical diagnostic techniques are based on the SARS-CoV-2 spike ectodomain that stabilizes the protein in the prefusion confo...

February 23, 2021 Many people associate a fresh snowfall with pleasures such as hot chocolate and winter sports. But for city dwellers, it also can mean caked-on salt that sticks to shoes, clothing hems and cars. That’s because as soon as the mercury dips below freezing and precipitation is in the forecast, local governments start spreading de-icing salts to keep roads from freezing over. De-icing salts also do extensive damage to autos, infrastructure and the environment. And cities use them in enormous quantities — nearly 20 million tons per year in the U.S. Snowbelt cities in Canada, E...

Researchers have detailed a mechanism in the distinctive corona of Covid-19 that could help scientists to rapidly find new treatments for the virus, and quickly test whether existing treatments are likely to work with mutated versions as they develop. The team, led by the University of Warwick as part of the EUTOPIA community of European universities, have simulated movements in nearly 300 protein structures of the Covid-19 virus spike protein by using computational modelling techniques, in an effort to help identify promising drug targets for the virus. In a new paper published today (19 Feb...

Scientists use computer simulations to identify future targets for treatment of Covid-19 University of Warwick scientists model movements of nearly 300 protein structures in Covid-19. Scientists can use the simulations to identify potential targets to test with existing drugs, and even check effectiveness with future Covid variants. Simulation of virus spike protein, part of the virus's corona', shows a promising mechanism that could potentially be blocked. Researchers have publicly released data on all protein structures to aid efforts to find potential drug targets. Researchers have detaile...

A recent study conducted by US scientists has demonstrated that the distribution of local topological free energy along the spike protein domains of SARS-CoV-2 is associated with their activity in protein rearrangement.