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Epigenetic regulation during cancer transitions across 11 tumour types

Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis1–4. Although the genetic contributions to oncogenic transitions have been investigated, epigenetic drivers remain less understood. Here we constructed a pan-cancer epigenetic and transcriptomic atlas using single-nucleus chromatin accessibility data (using single-nucleus assay for transposase-accessible chromatin) from 225 samples and matched single-cell or single-nucleus RNA-sequencing expression data from 206 samples. With over 1 million cells from each platform analysed through the enrichment of accessible chromatin regions, transcription factor motifs and regulons, we identified epigenetic drivers associated with cancer transitions. Some epigenetic drivers appeared in multiple cancers (for example, regulatory regions of ABCC1 and VEGFA; GATA6 and FOX-family motifs), wherea ....

United States , Featurematrix Signac , Rxm Leica Biosystems , Mycoalert Lonza , Perkin Elmer , Ensdb Hsapiens , Txdb Hsapiens , K Metstat Panel , Cell Signalling Technology , Xgen Exome Research Panel , Library Gel Bead Kit , Jackson Laboratory , International Cell Line Authentication Committee , Washington University School Of Medicine , Library Prep Kit , Cell Signaling Technology , Institutional Review Board , Washington University , Chromium Next , Cell Multiome , Gene Expression , Thermo Fisher Scientific , Genomics Single Indexn Set , Genomics Dual Index , Miltenyi Dead Cell Removal Kit , Genomics Chromium ,

Lab Accessories Market is expected to reach US$ 1.1 Billion by 2032, at a CAGR of 6.8%

Future Market Insights recently published a study projecting that the Lab Accessories Market demand will grow at a high CAGR of 6.8%, expanding from US$ 585.0 Million in 2022 to US$ 1.1 Billion by 2032. The report cites increasing availability of research funding, rapid technological advancements, and large-scale di. ....

United States , New York , Mikrosyteme Gmb , Greiner Bio , Biotix Inc , Lab Accessories For Hospitals , Intensification Of Research , Environmental Protection Agency , Lab Tubings , Lab Accessories , Lab Accessories For Research Institutes , Brooks Automation Inc , Gilson Inc , Corning Incorporated , Parker Hannifin Corporation , Lab Accessories Market Study , Image Technology , Heidolph Instruments Gmbh Co , Market Insights Inc , Lab Label Printers , Lab Accessories For Biotechnology , Lab Reagent Reservoirs , Lab Accessories For Academic Institutes , Lab Pipettes , Centers For Disease , Lab Pumps ,

Constructing NGS libraries for RNA-sequencing

In this article, Roche discusses a novel workflow for NGS library preparation that allows for much more efficient RNA-sequencing. ....

United States , Cape Town , Western Cape , South Africa , Rachel Kasinskas , Leendert Cloete , Kapa Biosystems , Alex Smith , Ida Van Jaarsveld , Jennifer Pavlica , Davis Todt , Library Prep Kit , Rd Team Leader Bioinformatics , Roche Diagnostics , Roche Pharmaceuticals , Library Quantification Kit For Illumina , Sponsored Content , Roche Sequencing , Life Scienceaug , New England Biolabs , Agilent Technologies , Agilent Expert , Prep Kit , Stranded Total , Ultra Directional , Quantification Kit ,

Top tips for RNA-sequencing that involves degraded inputs

In this article, Roche Diagnostics elucidates upon some of their top tips and recommendations for anyone performing RNA-sequencing with degraded RNA inputs and demonstrate how to improve efficiency and performance. ....

Tapestation Agilent , Alex Smith , Agilent Technologies , Roche Diagnostics , Library Quantification Kit , Sponsored Content , Roche Sequencing , Life Scienceaug , Prep Kit , Agilent Expert , Universal Human Reference , Image Credit , Quantification Kit , Fragment Analyzer , Advanced Analytical , High Sensitivity , Agilent High Sensitivity , Technical Data ,

Global Lab Accessories Market to Surpass the Billion Dollar Mark by 2032; Wash Stations to be Most Sought After: Future Market Insights, Inc.

/PRNewswire/ According to a recent study published by Future Market Insights, the lab accessories market is expected to reach US$ 1.1 Billion by 2032, up. ....

New York , United States , Mikrosyteme Gmb , Greiner Bio , Lab Accessories , Biotix Inc , Europe Lab Accessories Market , Lab Accessories For Research Institutes , Lab Valves , Lab Accessories For Biotechnology , Intensification Of Research , Hamilton Company , Centers For Disease , Environmental Protection Agency , World Health Organization , Brooks Automation Inc , Gilson Inc , Bio Rad Laboratories Inc , Market Insights Inc , Lab Tubings , Thermo Fisher Scientific Inc , Heidolph Instruments Gmbh Co , Lab Microplates , Parker Hannifin Corporation , Corning Incorporated , Vistalab Technologies Inc ,