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Epidemiology and outcomes of culture-positive bloodstream pathogens prior to and during the SARS-CoV-2 pandemic: a multicenter evaluation | BMC Infectious Diseases

Bloodstream infections (BSIs) are an important cause of morbidity and mortality in hospitalized patients. We evaluate incidence of community- and hospital-onset BSI rates and outcomes before and during the SARS-CoV-2 pandemic. We conducted a retrospective cohort study evaluating patients who were hospitalized for ≥ 1 day with discharge or death between June 1, 2019, and September 4, 2021, across 271 US health care facilities. Community- and hospital-onset BSI and related outcomes before and during the SARS-CoV-2 pandemic, including intensive care admission rates, and overall and ICU-specific length of stay (LOS) was evaluated. Bivariate correlations were calculated between the pre-pandemic and pandemic periods overall and by SARS-CoV-2 testing status. Of 5,239,692 patient admissions, there were 20,113 community-onset BSIs before the pandemic (11.2/1000 admissions) and 39,740 (11.5/1000 admissions) during the pandemic (P ≤ 0.0062). Correspond ....

United States , Franklin Lakes , Enterobacterales Citrobacter , Bd Insights Research Database Becton , Bd Insights Research Database , R Foundation For Statistical Computing , Research Database , New England Institutional Review Board , Observational Studies , Statistical Computing ,

High vaccine effectiveness against severe COVID-19 in the elderly in Finland before and after the emergence of Omicron | BMC Infectious Diseases

The elderly are highly vulnerable to severe COVID-19. Waning immunity and emergence of Omicron have caused concerns about reduced effectiveness of COVID-19 vaccines. The objective was to estimate vaccine effectiveness (VE) against severe COVID-19 among the elderly. This nationwide, register-based cohort analysis included all residents aged 70 years and over in Finland. The follow-up started on December 27, 2020, and ended on March 31, 2022. The outcomes of interest were COVID-19-related hospitalization and intensive care unit (ICU) admission timely associated with SARS-CoV-2 infection. VE was estimated as one minus the hazard ratio comparing the vaccinated and unvaccinated and taking into account time since vaccination. Omicron-specific VE was evaluated as the effectiveness observed since January 1, 2022. The cohort included 896,220 individuals. Comirnaty (BioNTech/Pfizer) VE against COVID-19-related hospitalization was 93% (95% CI 89–95%) and 85% (95% CI 82–87%) 1 ....

International Classification Of Diseases , Care Register For Health , National Infectious Diseases Register , National Vaccination Register , R Foundation For Statistical Computing , Population Information System , Care Register , Health Care , International Classification , Finnish Intensive Care Consortium , Quality Register , Intensive Care , Population Information , Social Care , Statistical Computing ,

Association Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease | Chronic Kidney Disease | JAMA

This retrospective cohort study assesses whether a longer interval between hemodialysis and subsequent surgery is associated with higher postoperative mortality ....

United States , Stanford University , Los Angeles , Arsiney Vasilev , Boehringer Ingelheim Lilly , University Of California , School Of Medicine , National Institute Of Diabetes , National Physician Fee Schedule Relative Value File , Stanford University School Of Medicine , Department Of Anesthesiology , Surgery Flags Software For Services , American Society Of Nephrology , Dana Farber Cancer Institute Novartis , R Foundation For Statistical Computing , National Institute , Centers For Medicare Medicaid Services , Clinical Classifications Software , National Institutes Of Health , David Geffen School Of Medicine , Bs Department Of Medicine , Us Census Bureau , National Kidney Foundation , American Community , Clinical Classifications Software For Services , Janssen Pharmaceuticals ,

Association of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among US Essential and Frontline Workers | Infectious Diseases | JAMA

This study uses a prospective cohort of essential and frontline workers in 6 US states with SARS-CoV-2 infection to examine associations between 2 or 3 doses of ....

United States , University Of Arizona , Salt Lake City , University Of Utah , Marshfield Clinic , University Of Miami , Katherine Ellingson , Sarangk Yoon , Tylerc Morrill , Jenna Praggastis , Thomasp Fabrizio , Elisha Stefanski , Matthew Brunner , Markg Thompson , Shawn Beitel , Jessica Lundgren , Schaefer Solle , Monica Dickerson , Edwardj Bedrick , Georgia Thompson , Adam Bissonnette , Deannae Fleary , Madison Bateman , Laurenew Olsho , Karen Lutrick , Marilynj Odean ,

Patients with asthma according to disease severity

Assessing the feasibility of the procedures of EPI-ASTHMA, a population-based multicentre study on the prevalence and characterization of patients with asthma ....

Vila Real , Eteläuomen Läi , Portuguese Health , Portuguese Sentinel Practice Network , Portuguese National Asthma , Ethics Board Committee , Portuguese National Program For Respiratory Diseases , Portuguese National Health Service , Denmark National Asthma , Group Asthma Characterization , Global Initiative For Asthma , R Foundation For Statistical Computing , Portuguese National Asthma Survey , Denmark National Asthma Surveys , Health Survey , Portuguese National Program , Respiratory Diseases , Global Initiative , Matosinhos Local Health Unit , North Region , Observational Studies , Epidemiology Statement , Data Collection Across Each Stage , Computer Assisted Telephone Interviews , Adult Asthma Epidemiological Score , Sub Group Asthma ,