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A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics | Infectious Diseases of Poverty

Dengue is the fastest spreading arboviral disease, posing great challenges on global public health. A reproduceable and comparable global genotyping framework for contextualizing spatiotemporal epidemiological data of dengue virus (DENV) is essential for research studies and collaborative surveillance. Targeting DENV-1 spreading prominently in recent decades, by reconciling all qualified complete E gene sequences of 5003 DENV-1 strains with epidemiological information from 78 epidemic countries/areas ranging from 1944 to 2018, we established and characterized a unified global high-resolution genotyping framework using phylogenetics, population genetics, phylogeography, and phylodynamics. The defined framework was discriminated with three hierarchical layers of genotype, subgenotype and clade with respective mean pairwise distances 2–6%, 0.8–2%, and ≤ 0.8%. The global epidemic patterns of DENV-1 showed strong geographic constraints representing stratified spatial ....

United States , South Korea , Republic Of Korea , Koichiro Tamura , Monte Carlo , Sudhir Kumar , Masatoshi Nei , Pennsylvania State University , R Foundation For Statistical Computing , Virus Pathogen Resource , Hierarchical Bayesian Analysis , Population Structure , Tabless B , Bayesian Skyline , Markov Chain Monte Carlo , Trace Tracer , Statistical Computing ,

Nutrition-related diseases and cardiovascular mortality in American society: national health and nutrition examination study, 1999–2006 | BMC Public Health

Despite many significant advances in treatment and management, cardiovascular disease remains the main cause of the global disease burden. Nutrition-related disease is a modifiable cardiovascular risk factor. However, few studies have examined the relationship between nutrition-related diseases and cardiovascular mortality. We aimed to investigate the association of nutrition-related diseases with cardiovascular mortality based on a large nationally representative community population. We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999–2006 with mortality follow-up through December 31, 2015. Finally, 12,469 participants were analyzed. Each participant was assigned to one of four groups: normal nutrition without sarcopenia, sarcopenia with normal nutrition, malnutrition without sarcopenia, and malnutrition-sarcopenia syndrome. Survival curves and Cox regressions based on the NHANES recommended weights were used to assess the association betwee ....

United States , Centers For Disease , Nutrition Examination Survey , Foundation For The National Institutes Of Health , National Center , International Classification Of Diseases , National Health , National Death Index , Hologic Inc , Health Statistics , R Foundation For Statistical Computing , Disease Control , National Institutes , Controlling Nutritional Status , Supplementary Table , Accessed July , International Classification , Statistical Computing ,

Acute exposure to air pollutants increase the risk of acute glaucoma | BMC Public Health

Ambient air pollution is related to the onset and progression of ocular disease. However, the effect of air pollutants on the acute glaucoma remains unclear. To investigate the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucoma and glaucomatocyclitic crisis) among adults. We conducted a time-stratified case-crossover study based on the data of glaucoma outpatients from January, 2015 to Dec, 2021 in Shanghai, China. A conditional logistic regression model combined with a polynomial distributed lag model was applied for the statistical analysis. Each case serves as its own referent by comparing exposures on the day of the outpatient visit to the exposures on the other 3–4 control days on the same week, month and year. To fully capture the delayed effect of air pollution, we used a maximum lag of 7 days in main model. A total of 14,385 acute glaucoma outpatients were included in this study. We found exposure to PM2.5, PM10, nitrogen dioxi ....

Eteläuomen Läi , China National Urban Air Quality Publishing Platform , China Meteorological Data Sharing Service System , Throat Hospital Of Fudan University , R Foundation For Statistical Computing , Eye Ear Nose , Throat Hospital , Fudan University , Xinhua Hospital Affiliated , Shanghai Jiao Tong University School , Institutional Review Board , National Urban Air Quality Real Time Publishing , Statistical Computing ,