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More Relief for Crohn's on the Horizon With New Treatments

IBD doesn't have a cure, and treatments are often limited. But, in recent years, gastrointestinal researchers have sharply focused on solutions for the disease overall and Crohn's in particular.

Canada , California , United-states , Americans , Maneesh-dave , Arun-sharma , Neal-leleiko , University-of-california , Northwestern-feinberg-school-of-medicine , Columbia-university , Northwestern-university , Mccormick-school-of-engineering

Drug Prototype Promising in Treatment of Pulmonary Disease

Proof-of-concept study supported potential of drug-like small molecule to promote lung tissue repair.

California , United-states , San-diego , Baylor-college-of-medicine , Texas , Houston , Michaelj-bollong , Dharanik-narendra , Department-of-chemistry-at-scripps-research , Calibr-skaggs-institute-for-innovative-medicines , Proceedings-of-the-national-academy-sciences

Better Outcomes With Early HETs in Pediatric-Onset MS

Early initiation of HET in pediatric-onset MS was linked to slower progression to disability compared to treatment with low-efficacy therapy or no treatment.

Toronto , Ontario , Canada , Melbourne , Victoria , Australia , Italy , Italian , Sifat-sharman , E-ann-yeh , Department-of-medicine , University-of-melbourne

Common Household Chemicals Tied to Brain Cell Damage

Two classes of pervasive environmental chemicals that are present in household cleaners, furniture and electronics had "surprising" effects specifically on the non-nerve cells in the brain.

Ohio , United-states , Florida , Miami , New-york , Cleveland , Sarah-evans , Shaheen-lakhan , Paul-tesar , Nutrition-examination , Department-of-environmental-medicine , Case-western-reserve-university-school-of-medicine

Multiple Myeloma: What Treatments Work Best?

The longest overall survival of nearly 8-10 years was with autologous stem cell transplantation.

Denmark , Sweden , Odense , Syddanmark , Finland , Niels-abildgaard , Odense-university-hospital , Takeda-pharmaceuticals-international , European-journal , Multiple-myeloma , Yeloma , Lasma-cell-myeloma

Tools on the Horizon for Managing Posttransplant cSCC Risk

Organ transplant recipients have a 200-fold increased incidence of keratinocyte carcinoma compared with immunocompetent individuals, and cSCC accounts for 80% of skin cancers in those recipients.

Yale-university , Connecticut , United-states , San-francisco , California , American , Johns-hopkins , Sean-christensen , Matthew-bottomley , Sarah-arron , Drug-administration , University-of-oxford

CRISPR-Based Gene Therapy Earns Beta Thalassemia Approval

Exa-cel earned its second FDA approval. The one-time therapy, which has a list price of $2.2 million in the United States, should be available for patients early this year.

United-states , Drug-administration , Vertex-pharmaceutical , Genomics-genomic-medicine , Beta-thalassemia , Crispr , Lustered-regularly-interspaced-short-palindromic-repeats , Rispr-cas9 , Thalassemia-thalassaemia , Biologic-therapy , Iologics

Vertex Pauses Islet Cell Study After Patient Deaths

The deaths are unrelated to the investigational allogeneic stem cell–derived product VX-880, the company says.

New-york , United-states , Boston , Massachusetts , American , European-association-for-the-study-of-diabetes , Facebook , Vertex-pharmaceuticals-inc , American-diabetes-association , New-york-times , Vertex-pharmaceuticals

This Frontline Therapy Is Better in Multiple Myeloma: Study

A study directly comparing real-world outcomes suggests patients with transplant-ineligible multiple myeloma do better with frontline triple therapy with daratumumab vs bortezomib.

United-states , Florida , American , Dorisk-hansen , American-society-of-hematology , National-comprehensive-cancer-network , Moffitt-cancer-center-research-institute-in-tampa , Moffitt-cancer-center , Research-institute , American-society , Multiple-myeloma

No Benefit to Salvage Transplant in R/R Multiple Myeloma

Long-term follow-up shows no progression-free or overall survival advantage among patients who received salvage transplant vs continuous lenalidomide plus dexamethasone.

Salt-lake-city , Utah , United-states , Heidelberg , Baden-wüberg , Germany , University-of-utah , German , American , Manni-mohyuddin , Marc-andrea-baertsch , University-hospital-heidelberg