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Novel protein construct prevents lethal COVID-19 in mice

Novel protein construct prevents lethal COVID-19 in mice
Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
The team engineered a soluble, short, and dimeric version of the native host cell receptor that is bound by a surface structure on SARS-CoV-2 called spike during the initial stage of the infection process.
The team – from the Feinberg School of Medicine in Chicago, the University of Chicago, and Northwestern University in Evanston – suspected that a soluble, truncated version of this membrane-bound receptor – called angiotensin-converting enzyme 2 (ACE2) – would serve as a decoy for SARS-CoV-2 spike binding and potentially neutralize infection. ....

United States , University Of Chicago , Daniel Batlle , Sally Robertson , Feinberg School Of Medicine , Northwestern University In Evanston , Feinberg School , Northwestern University , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , In Vitro , In Vivo , Mouse Model , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , சாலி ராபர்ட்சன் , ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , வடமேற்கு பல்கலைக்கழகம் இல் எவன்ஸ்டன் , ஃபைன்பெர்க் பள்ளி , வடமேற்கு பல்கலைக்கழகம் , பிணைப்பு இன உறவு ,

Combination therapy may reduce influenza-associated morbidity and mortality

Combination therapy may reduce influenza-associated morbidity and mortality
A significant proportion of hospitalized patients with influenza develop complications of acute respiratory distress syndrome, driven by virus-induced cytopathic effects as well as exaggerated host immune response. Reporting in
The American Journal of Pathology, published by Elsevier, investigators have found that treatment with an immune receptor blocker in combination with an antiviral agent markedly improves survival of mice infected with lethal influenza and reduces lung pathology in swine-influenza-infected piglets. Their research also provides insights into the optimal timing of treatment to prevent acute lung injury.
Previously, the investigators found that an excessive influx of neutrophils, infection fighting immune cells, and the networks they create to kill pathogens, known as neutrophil extracellular traps (NETs), contribute to acute lung injury in influenza infection. Formation of ....

United States , Narasaraju Teluguakula , Emily Henderson , Veterinary Health Sciences , Oklahoma State University , American Journal , Lead Investigator , Acute Respiratory Distress Syndrome , Immune Response , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , கால்நடை ஆரோக்கியம் அறிவியல் , ஓக்லஹோமா நிலை பல்கலைக்கழகம் , அமெரிக்கன் இதழ் , வழி நடத்து புலனாய்வாளர் , எடுப்போசை சுவாச துன்பம் நோய்க்குறி , நோய் எதிர்ப்பு சக்தி பதில் , நோயியல் இயற்பியல் ,

New research proposes innovative antibody-based treatment to prevent SARS-CoV-2 viral entry

New research proposes innovative antibody-based treatment to prevent SARS-CoV-2 viral entry
A brief report by researchers at the University of Virginia, USA, proposes using an antibody-based treatment with a plug-and-play strategy to inhibit the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to invade human cells.
The spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) receptors found on human cells, allowing it to gain entry and take over the cell’s machinery for replication.
The treatment results show it works by blocking the host protease-activation function of the spike protein one of the first steps needed for viral entry. ....

United States , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , University Of Virginia , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , பல்கலைக்கழகம் ஆஃப் வர்ஜீனியா , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Saliva-based testing as a method for monitoring population immunity to SARS-CoV-2 infection

Saliva-based testing as a method for monitoring population immunity to SARS-CoV-2 infection
Researchers in the United States have shown that saliva-based sampling could serve as an accurate and non-invasive alternative to blood sampling for monitoring people’s antibody responses following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vaccination against the virus.
The SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that continues to pose a threat to global public health and has now caused more than 2.66 million deaths worldwide.
Christopher Heaney from Johns Hopkins University in Baltimore and colleagues assessed the durability of immunoglobulin G (IgG) antibodies against three SARS-CoV-2 antigens in saliva samples collected from more than 200 people up to 8 months after they tested positive for the virus. ....

United States , Christopher Heaney , Sally Robertson , Johns Hopkins University In Baltimore , Antigen Company , Johns Hopkins University , Native Antigen Company , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Public Health , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , கிறிஸ்டோபர் ஹீனி , சாலி ராபர்ட்சன் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் இல் பால்டிமோர் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , கொரோனா வைரஸ் , சர்வதேச பரவல் , பொது ஆரோக்கியம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis
TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models. They found that TARM1 activated dendritic cells, and development of collagen-induced arthritis (CIA) was notably suppressed in TARM1-deficient mice and by treatment with TARM1-inhibitory soluble TARM1 proteins. This makes the protein a potential therapeutic target.
Autoimmune diseases are typically caused when the immune system, whose purpose is to deal with foreign threats to the body, incorrectly recognizes the body s own proteins and cells as threats and activates immune cells to attack them. In the case of rheumatoid arthritis, a well-known autoimmune disease, immune cells erroneously attack the body s own joint components and proteins, caus ....

Yoichiro Iwakura , Rikio Yabe , Shinobu Saijo , Emily Henderson , Nature Communications , Tokyo University Of Science , Chiba University , Professor Yoichiro Iwakura , Tokyo University , Autoimmune Disease , Immune Response , Immune System , Rheumatoid Arthritis , ஷினோபு சைஜோ , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , டோக்கியோ பல்கலைக்கழகம் ஆஃப் அறிவியல் , சிபா பல்கலைக்கழகம் , டோக்கியோ பல்கலைக்கழகம் , ஆட்டோ இம்யூன் நோய் , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி அமைப்பு , முடக்கு கீல்வாதம் ,